Non-viral charge reversal vectors for pDNA delivery.

Journal Article

A synthetic vector that transform from a cationic to an anionic lipid intracellularly is described. This charge-reversal lipid was synthesized and characterized, including the supramolecular complex it forms with DNA. Enhanced gene transfection was observed using this synthetic vector compared to current cationic lipids.

Duke Authors

Cited Authors

  • Prata, CAH; Li, Y; Luo, D; McIntosh, TJ; Grinstaff, MW

Published Date

  • 2006

Published In

Start / End Page

  • 4347 - 4349

International Standard Serial Number (ISSN)

  • 1557-170X