Skip to main content

Modulation of HIV-1 immunity by adjuvants

Publication ,  Journal Article
Moody, MA
Published in: Current Opinion in HIV and AIDS
2014

Purpose of Review: To summarize the role of adjuvants in eliciting desirable antibody responses against HIV-1 with particular emphasis on both historical context and recent developments. RECENT FINDINGS: Increased understanding of the role of pattern recognition receptors such as Toll-like receptors in recruiting and directing the immune system has increased the variety of adjuvant formulations being tested in animal models and humans. Across all vaccine platforms, adjuvant formulations have been shown to enhance desirable immune responses such as higher antibody titers and increased functional activity. Although no vaccine formulation has yet succeeded in eliciting broad neutralizing antibodies against HIV-1, the ability of adjuvants to direct the immune response to immunogens suggests they will be critically important in any successful HIV-1 vaccine. SUMMARY: The parallel development of adjuvants along with better HIV-1 immunogens will be needed for a successful AIDS vaccine. Additional comparative testing will be required to determine the optimal adjuvant and immunogen regimen that can elicit antibody responses capable of blocking HIV-1 transmission. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Current Opinion in HIV and AIDS

DOI

ISSN

1746-630X

Publication Date

2014

Volume

9

Issue

3

Start / End Page

242 / 249

Related Subject Headings

  • Virology
  • 1117 Public Health and Health Services
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Moody, M. A. (2014). Modulation of HIV-1 immunity by adjuvants. Current Opinion in HIV and AIDS, 9(3), 242–249. https://doi.org/10.1097/COH.0000000000000052
Moody, M. A. “Modulation of HIV-1 immunity by adjuvants.” Current Opinion in HIV and AIDS 9, no. 3 (2014): 242–49. https://doi.org/10.1097/COH.0000000000000052.
Moody MA. Modulation of HIV-1 immunity by adjuvants. Current Opinion in HIV and AIDS. 2014;9(3):242–9.
Moody, M. A. “Modulation of HIV-1 immunity by adjuvants.” Current Opinion in HIV and AIDS, vol. 9, no. 3, 2014, pp. 242–49. Scival, doi:10.1097/COH.0000000000000052.
Moody MA. Modulation of HIV-1 immunity by adjuvants. Current Opinion in HIV and AIDS. 2014;9(3):242–249.

Published In

Current Opinion in HIV and AIDS

DOI

ISSN

1746-630X

Publication Date

2014

Volume

9

Issue

3

Start / End Page

242 / 249

Related Subject Headings

  • Virology
  • 1117 Public Health and Health Services