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Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance)

Publication ,  Journal Article
Chhibber, A; Mefford, J; Stahl, EA; Pendergrass, SA; Baldwin, RM; Owzar, K; Li, M; Winer, EP; Hudis, CA; Zembutsu, H; Kubo, M; Nakamura, Y ...
Published in: Pharmacogenomics Journal
January 1, 2014

Peripheral neuropathy is a common dose-limiting toxicity for patients treated with paclitaxel. For most individuals, there are no known risk factors that predispose patients to the adverse event, and pathogenesis for paclitaxel-induced peripheral neuropathy is unknown. Determining whether there is a heritable component to paclitaxel-induced peripheral neuropathy would be valuable in guiding clinical decisions and may provide insight into treatment of and mechanisms for the toxicity. Using genotype and patient information from the paclitaxel arm of CALGB 40101 (Alliance), a phase III clinical trial evaluating adjuvant therapies for breast cancer in women, we estimated the variance in maximum grade and dose at first instance of sensory peripheral neuropathy. Our results suggest that paclitaxel-induced neuropathy has a heritable component, driven in part by genes involved in axon outgrowth. Disruption of axon outgrowth may be one of the mechanisms by which paclitaxel treatment results in sensory peripheral neuropathy in susceptible patients. © 2014 Macmillan Publishers Limited All rights reserved.

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Published In

Pharmacogenomics Journal

DOI

EISSN

1473-1150

ISSN

1470-269X

Publication Date

January 1, 2014

Volume

14

Issue

4

Start / End Page

336 / 342

Related Subject Headings

  • Pharmacology & Pharmacy
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Chhibber, A., Mefford, J., Stahl, E. A., Pendergrass, S. A., Baldwin, R. M., Owzar, K., … Kroetz, D. L. (2014). Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance). Pharmacogenomics Journal, 14(4), 336–342. https://doi.org/10.1038/tpj.2014.2
Chhibber, A., J. Mefford, E. A. Stahl, S. A. Pendergrass, R. M. Baldwin, K. Owzar, M. Li, et al. “Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).” Pharmacogenomics Journal 14, no. 4 (January 1, 2014): 336–42. https://doi.org/10.1038/tpj.2014.2.
Chhibber A, Mefford J, Stahl EA, Pendergrass SA, Baldwin RM, Owzar K, et al. Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance). Pharmacogenomics Journal. 2014 Jan 1;14(4):336–42.
Chhibber, A., et al. “Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).” Pharmacogenomics Journal, vol. 14, no. 4, Jan. 2014, pp. 336–42. Scopus, doi:10.1038/tpj.2014.2.
Chhibber A, Mefford J, Stahl EA, Pendergrass SA, Baldwin RM, Owzar K, Li M, Winer EP, Hudis CA, Zembutsu H, Kubo M, Nakamura Y, McLeod HL, Ratain MJ, Shulman LN, Ritchie MD, Plenge RM, Witte JS, Kroetz DL. Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance). Pharmacogenomics Journal. 2014 Jan 1;14(4):336–342.

Published In

Pharmacogenomics Journal

DOI

EISSN

1473-1150

ISSN

1470-269X

Publication Date

January 1, 2014

Volume

14

Issue

4

Start / End Page

336 / 342

Related Subject Headings

  • Pharmacology & Pharmacy
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences