Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism.

Journal Article (Journal Article;Review)

Thyroid hormone (TH) has important roles in regulating hepatic lipid, cholesterol, and glucose metabolism. Recent findings suggest that clinical conditions such as non-alcoholic fatty liver disease and type 2 diabetes mellitus, which are associated with dysregulated hepatic metabolism, may involve altered intracellular TH action. In addition, TH has key roles in lipophagy in lipid metabolism, mitochondrial quality control, and the regulation of metabolic genes. In this review, we discuss recent findings regarding the functions of TH in hepatic metabolism, the relationship between TH and metabolic disorders, and the potential therapeutic use of thyromimetics to treat metabolic dysfunction in the liver.

Full Text

Duke Authors

Cited Authors

  • Sinha, RA; Singh, BK; Yen, PM

Published Date

  • October 2014

Published In

Volume / Issue

  • 25 / 10

Start / End Page

  • 538 - 545

PubMed ID

  • 25127738

Electronic International Standard Serial Number (EISSN)

  • 1879-3061

Digital Object Identifier (DOI)

  • 10.1016/j.tem.2014.07.001


  • eng

Conference Location

  • United States