D-Dimer elevation and adverse outcomes.
Journal Article (Journal Article;Review)
D-Dimer is a biomarker of fibrin formation and degradation. While a D-dimer within normal limits is used to rule out the diagnosis of deep venous thrombosis and pulmonary embolism among patients with a low clinical probability of venous thromboembolism (VTE), the prognostic association of an elevated D-dimer with adverse outcomes has received far less emphasis. An elevated D-dimer is independently associated with an increased risk for incident VTE, recurrent VTE, and mortality. An elevated D-dimer is an independent correlate of increased mortality and subsequent VTE across a broad variety of disease states. Therefore, medically ill subjects in whom the D-dimer is elevated constitute a high risk subgroup in which the prospective evaluation of the efficacy and safety of antithrombotic therapy is warranted.
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Duke Authors
Cited Authors
- Halaby, R; Popma, CJ; Cohen, A; Chi, G; Zacarkim, MR; Romero, G; Goldhaber, SZ; Hull, R; Hernandez, A; Mentz, R; Harrington, R; Lip, G; Peacock, F; Welker, J; Martin-Loeches, I; Daaboul, Y; Korjian, S; Gibson, CM
Published Date
- January 2015
Published In
Volume / Issue
- 39 / 1
Start / End Page
- 55 - 59
PubMed ID
- 25006010
Pubmed Central ID
- PMC4300425
Electronic International Standard Serial Number (EISSN)
- 1573-742X
Digital Object Identifier (DOI)
- 10.1007/s11239-014-1101-6
Language
- eng
Conference Location
- Netherlands