D-Dimer elevation and adverse outcomes.

Journal Article (Journal Article;Review)

D-Dimer is a biomarker of fibrin formation and degradation. While a D-dimer within normal limits is used to rule out the diagnosis of deep venous thrombosis and pulmonary embolism among patients with a low clinical probability of venous thromboembolism (VTE), the prognostic association of an elevated D-dimer with adverse outcomes has received far less emphasis. An elevated D-dimer is independently associated with an increased risk for incident VTE, recurrent VTE, and mortality. An elevated D-dimer is an independent correlate of increased mortality and subsequent VTE across a broad variety of disease states. Therefore, medically ill subjects in whom the D-dimer is elevated constitute a high risk subgroup in which the prospective evaluation of the efficacy and safety of antithrombotic therapy is warranted.

Full Text

Duke Authors

Cited Authors

  • Halaby, R; Popma, CJ; Cohen, A; Chi, G; Zacarkim, MR; Romero, G; Goldhaber, SZ; Hull, R; Hernandez, A; Mentz, R; Harrington, R; Lip, G; Peacock, F; Welker, J; Martin-Loeches, I; Daaboul, Y; Korjian, S; Gibson, CM

Published Date

  • January 2015

Published In

Volume / Issue

  • 39 / 1

Start / End Page

  • 55 - 59

PubMed ID

  • 25006010

Pubmed Central ID

  • PMC4300425

Electronic International Standard Serial Number (EISSN)

  • 1573-742X

Digital Object Identifier (DOI)

  • 10.1007/s11239-014-1101-6


  • eng

Conference Location

  • Netherlands