D-Dimer elevation and adverse outcomes.
Journal Article (Journal Article;Review)
D-Dimer is a biomarker of fibrin formation and degradation. While a D-dimer within normal limits is used to rule out the diagnosis of deep venous thrombosis and pulmonary embolism among patients with a low clinical probability of venous thromboembolism (VTE), the prognostic association of an elevated D-dimer with adverse outcomes has received far less emphasis. An elevated D-dimer is independently associated with an increased risk for incident VTE, recurrent VTE, and mortality. An elevated D-dimer is an independent correlate of increased mortality and subsequent VTE across a broad variety of disease states. Therefore, medically ill subjects in whom the D-dimer is elevated constitute a high risk subgroup in which the prospective evaluation of the efficacy and safety of antithrombotic therapy is warranted.
- Published version (via Digital Object Identifier)
- Pubmed Central version
- Open Access Copy from Duke
- Link to Item
- Halaby, R; Popma, CJ; Cohen, A; Chi, G; Zacarkim, MR; Romero, G; Goldhaber, SZ; Hull, R; Hernandez, A; Mentz, R; Harrington, R; Lip, G; Peacock, F; Welker, J; Martin-Loeches, I; Daaboul, Y; Korjian, S; Gibson, CM
- January 2015
Volume / Issue
- 39 / 1
Start / End Page
- 55 - 59
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)