Measuring social communication behaviors as a treatment endpoint in individuals with autism spectrum disorder.

Journal Article (Journal Article;Review)

Social communication impairments are a core deficit in autism spectrum disorder. Social communication deficit is also an early indicator of autism spectrum disorder and a factor in long-term outcomes. Thus, this symptom domain represents a critical treatment target. Identifying reliable and valid outcome measures for social communication across a range of treatment approaches is essential. Autism Speaks engaged a panel of experts to evaluate the readiness of available measures of social communication for use as outcome measures in clinical trials. The panel held monthly conference calls and two face-to-face meetings over 14 months. Key criteria used to evaluate measures included the relevance to the clinical target, coverage of the symptom domain, and psychometric properties (validity and reliability, as well as evidence of sensitivity to change). In all, 38 measures were evaluated and 6 measures were considered appropriate for use, with some limitations. This report discusses the relative strengths and weaknesses of existing social communication measures for use in clinical trials and identifies specific areas in need of further development.

Full Text

Duke Authors

Cited Authors

  • Anagnostou, E; Jones, N; Huerta, M; Halladay, AK; Wang, P; Scahill, L; Horrigan, JP; Kasari, C; Lord, C; Choi, D; Sullivan, K; Dawson, G

Published Date

  • July 2015

Published In

Volume / Issue

  • 19 / 5

Start / End Page

  • 622 - 636

PubMed ID

  • 25096930

Electronic International Standard Serial Number (EISSN)

  • 1461-7005

Digital Object Identifier (DOI)

  • 10.1177/1362361314542955


  • eng

Conference Location

  • England