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Driving ability reported by neovascular age-related macular degeneration patients after treatment with ranibizumab.

Publication ,  Journal Article
Bressler, NM; Chang, TS; Varma, R; Suñer, I; Lee, P; Dolan, CM; Ward, J; Ianchulev, T; Fine, J
Published in: Ophthalmology
January 2013

OBJECTIVES: To determine the impact of ranibizumab on driving status, driving ability perception, and having 20/40 vision or better in patients with choroidal neovascularization resulting from age-related macular degeneration (AMD). DESIGN: Phase III, multicenter, randomized clinical trials (Minimally Classic/Occult Trial of the Anti-VEGF Antibody Ranibizumab in the Treatment of Neovascular Age-Related Macular Degeneration [MARINA] and Anti-VEGF Antibody for the Treatment of Predominantly Classic Choroidal Neovascularization in Age-Related Macular Degeneration [ANCHOR]). PARTICIPANTS: One thousand one hundred twenty-six patients with choroidal neovascularization resulting from AMD. METHODS: Participants were assigned randomly to sham (n=238), 0.3-mg ranibizumab monthly injections (n=238), or 0.5-mg ranibizumab monthly injections (n=240) for 24 months (MARINA), or were randomized to verteporfin photodynamic therapy (PDT; n=143), 0.3-mg ranibizumab monthly injections (n=140), or 0.5-mg ranibizumab monthly injections (n=140) for 24 months (ANCHOR). MAIN OUTCOME MEASURES: Self-reported driving status and driving ability perception were assessed as exploratory outcomes at baseline through 24 months after baseline using the 25-item National Eye Institute Visual Function Questionnaire. Best-corrected visual acuity in each eye was assessed monthly through 24 months. RESULTS: At baseline, 68.6% of patients in the MARINA trial and 62.7% of patients in the ANCHOR trial reported driving. Among patients driving at baseline in the MARINA trial 2 years after randomization, 67.2% (95% confidence interval [CI], 59.2-75.2) of sham patients and 78.4% (95% CI, 71.8-85.0) of 0.5-mg patients reported that they were still driving. Among patients driving at baseline in the ANCHOR trial at 2 years after randomization, 71.6% (95% CI, 60.8-82.4) of PDT patients and 91.4% (95% CI, 85.3-97.5) of 0.5-mg patients were still driving. Also in the ANCHOR trial, ranibizumab-treated patients who were not driving at baseline seemed more likely to drive by months 12 and 24 than PDT patients. Perception of driving ability was correlated with improvement in visual acuity (VA) in the better-seeing eye at 12 and 24 months (R2=0.17 and R2=0.20 at 12 and 24 months, respectively [P<0.001], in the MARINA trial; R2=0.13 and R2=0.14, respectively [P<0.001], in the ANCHOR trial). Visual acuity in one or both eyes 2 years after randomization was more likely to be 20/40 or better in the ranibizumab-treated groups. CONCLUSIONS: These results suggest that patients with neovascular AMD treated with ranibizumab are more likely to report driving ability and have vision of at least 20/40 than patients given sham treatment or PDT. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.

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Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

January 2013

Volume

120

Issue

1

Start / End Page

160 / 168

Location

United States

Related Subject Headings

  • Wet Macular Degeneration
  • Visual Acuity
  • Vision, Low
  • Verteporfin
  • Sickness Impact Profile
  • Self Report
  • Ranibizumab
  • Porphyrins
  • Photosensitizing Agents
  • Photochemotherapy
 

Citation

APA
Chicago
ICMJE
MLA
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Bressler, N. M., Chang, T. S., Varma, R., Suñer, I., Lee, P., Dolan, C. M., … Fine, J. (2013). Driving ability reported by neovascular age-related macular degeneration patients after treatment with ranibizumab. Ophthalmology, 120(1), 160–168. https://doi.org/10.1016/j.ophtha.2012.07.027
Bressler, Neil M., Tom S. Chang, Rohit Varma, Ivan Suñer, Paul Lee, Chantal M. Dolan, James Ward, Tsontcho Ianchulev, and Jennifer Fine. “Driving ability reported by neovascular age-related macular degeneration patients after treatment with ranibizumab.Ophthalmology 120, no. 1 (January 2013): 160–68. https://doi.org/10.1016/j.ophtha.2012.07.027.
Bressler NM, Chang TS, Varma R, Suñer I, Lee P, Dolan CM, et al. Driving ability reported by neovascular age-related macular degeneration patients after treatment with ranibizumab. Ophthalmology. 2013 Jan;120(1):160–8.
Bressler, Neil M., et al. “Driving ability reported by neovascular age-related macular degeneration patients after treatment with ranibizumab.Ophthalmology, vol. 120, no. 1, Jan. 2013, pp. 160–68. Pubmed, doi:10.1016/j.ophtha.2012.07.027.
Bressler NM, Chang TS, Varma R, Suñer I, Lee P, Dolan CM, Ward J, Ianchulev T, Fine J. Driving ability reported by neovascular age-related macular degeneration patients after treatment with ranibizumab. Ophthalmology. 2013 Jan;120(1):160–168.
Journal cover image

Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

January 2013

Volume

120

Issue

1

Start / End Page

160 / 168

Location

United States

Related Subject Headings

  • Wet Macular Degeneration
  • Visual Acuity
  • Vision, Low
  • Verteporfin
  • Sickness Impact Profile
  • Self Report
  • Ranibizumab
  • Porphyrins
  • Photosensitizing Agents
  • Photochemotherapy