Relationship of body mass index and GAD65 antibody status on β-cell secretion at diabetes onset in African-American children.

Journal Article (Journal Article)

Abstract Body mass and anti-pancreatic antibody status potentially influences the presentation of diabetes in children. We hypothesized that anti-pancreatic auto-antibody positive patients with new onset diabetes would have lower levels of insulin and C-peptide at presentation, and hence higher HbA1c. Records of children with new onset diabetes self-identified as African American were retrospectively analyzed. Patients were under 19 years of age. Anti-GAD65 antibody titer, HbA1c, blood glucose, insulin and C-peptide levels were drawn at the time of diagnosis. Patients were classified as antibody positive if anti-GAD65 was ≥ 0.5. HbA1c, insulin and C-peptide levels were considered as dependent variables in statistical models that included auto-antibody status, gender, age, body mass index z score (BMI-z score), and blood glucose as independent covariates. Records of 61 African-American children were available for analysis. There was no statistical association of auto-antibody status or initial clinical diagnosis with HbA1c, insulin or C-peptide level. BMI-z score was strongly associated with insulin (p=0.0006) and C-peptide (p<0.0001) levels. In general, higher BMI-z score, female gender and older age were associated with higher C-peptide levels. Although potentially helpful in eventually determining etiology, pancreatic auto-antibody levels do not have an association with HbA1c, insulin or C-peptide levels in African-American children with new onset diabetes. BMI-z score had the most robust association with insulin and C-peptide levels at presentation.

Full Text

Duke Authors

Cited Authors

  • Balikcioglu, PG; Balikcioglu, M; Gómez, R; Vargas, A; Chalew, SA

Published Date

  • 2013

Published In

Volume / Issue

  • 26 / 11-12

Start / End Page

  • 1087 - 1091

PubMed ID

  • 23828489

Pubmed Central ID

  • 23828489

Electronic International Standard Serial Number (EISSN)

  • 2191-0251

Digital Object Identifier (DOI)

  • 10.1515/jpem-2013-0138


  • eng

Conference Location

  • Germany