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New oral anticoagulant-induced bleeding: clinical presentation and management.

Publication ,  Other
Levy, JH; Levi, M
Published in: Clin Lab Med
September 2014

Bleeding is a significant complication of anticoagulant therapy. With the emergence of new oral anticoagulants (NOACs; ie, direct factor IIa or Xa inhibitors), this risk is further compounded by the lack of validated reversal strategies for these agents. Emerging postmarketing evidence suggests that the bleeding risks are in line with results observed in head-to-head clinical trials of NOACs versus traditional anticoagulants. Several guidelines have recommended the use of hemostatic agents for NOAC reversal in patients with life-threatening bleeding. Ultimately, adequately powered studies will be crucial for full assessment of the effectiveness and safety of any proposed reversal strategies.

Duke Scholars

Published In

Clin Lab Med

DOI

EISSN

1557-9832

Publication Date

September 2014

Volume

34

Issue

3

Start / End Page

575 / 586

Location

United States

Related Subject Headings

  • Risk
  • Practice Guidelines as Topic
  • Pathology
  • Humans
  • Hemorrhage
  • Factor Xa Inhibitors
  • Evidence-Based Medicine
  • Antithrombins
  • Anticoagulants
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Levy, J. H., & Levi, M. (2014). New oral anticoagulant-induced bleeding: clinical presentation and management. Clin Lab Med. United States. https://doi.org/10.1016/j.cll.2014.06.004
Levy, Jerrold H., and Marcel Levi. “New oral anticoagulant-induced bleeding: clinical presentation and management.Clin Lab Med, September 2014. https://doi.org/10.1016/j.cll.2014.06.004.
Levy JH, Levi M. New oral anticoagulant-induced bleeding: clinical presentation and management. Vol. 34, Clin Lab Med. 2014. p. 575–86.
Levy, Jerrold H., and Marcel Levi. “New oral anticoagulant-induced bleeding: clinical presentation and management.Clin Lab Med, vol. 34, no. 3, Sept. 2014, pp. 575–86. Pubmed, doi:10.1016/j.cll.2014.06.004.
Journal cover image

Published In

Clin Lab Med

DOI

EISSN

1557-9832

Publication Date

September 2014

Volume

34

Issue

3

Start / End Page

575 / 586

Location

United States

Related Subject Headings

  • Risk
  • Practice Guidelines as Topic
  • Pathology
  • Humans
  • Hemorrhage
  • Factor Xa Inhibitors
  • Evidence-Based Medicine
  • Antithrombins
  • Anticoagulants
  • Animals