Identification and synthesis of quinolizidines with anti-influenza a virus activity.

Journal Article

Influenza A virus infection causes a contagious respiratory illness that poses a threat to human health. However, there are limited anti-influenza A therapeutics available, which is further compounded by the emergence of drug resistant viruses. In this study, Sophora quinolizidine alkaloids were identified as a new class of anti-influenza A virus agents. Among the tested Sophora alkaloids, dihydroaloperine exhibited the most potent activity with an EC50 of 11.2 μM. The potency of the quinolizidine alkaloids was improved by approximately 5-fold with chemical modifications on the aloperine molecule. These compounds were effective against an H1N1 influenza A virus that was resistant to the two antiflu drugs oseltamivir and amantadine. The identification of the quinolizidine alkaloids as effective and novel anti-influenza A agents may aid in the development of new therapeutics.

Full Text

Duke Authors

Cited Authors

  • Dang, Z; Jung, K; Zhu, L; Lai, W; Xie, H; Lee, K-H; Huang, L; Chen, C-H

Published Date

  • August 2014

Published In

Volume / Issue

  • 5 / 8

Start / End Page

  • 942 - 946

PubMed ID

  • 25147619

Pubmed Central ID

  • 25147619

Electronic International Standard Serial Number (EISSN)

  • 1948-5875

International Standard Serial Number (ISSN)

  • 1948-5875

Digital Object Identifier (DOI)

  • 10.1021/ml500236n

Language

  • eng