Identification and synthesis of quinolizidines with anti-influenza a virus activity.
Journal Article (Journal Article)
Influenza A virus infection causes a contagious respiratory illness that poses a threat to human health. However, there are limited anti-influenza A therapeutics available, which is further compounded by the emergence of drug resistant viruses. In this study, Sophora quinolizidine alkaloids were identified as a new class of anti-influenza A virus agents. Among the tested Sophora alkaloids, dihydroaloperine exhibited the most potent activity with an EC50 of 11.2 μM. The potency of the quinolizidine alkaloids was improved by approximately 5-fold with chemical modifications on the aloperine molecule. These compounds were effective against an H1N1 influenza A virus that was resistant to the two antiflu drugs oseltamivir and amantadine. The identification of the quinolizidine alkaloids as effective and novel anti-influenza A agents may aid in the development of new therapeutics.
Full Text
Duke Authors
Cited Authors
- Dang, Z; Jung, K; Zhu, L; Lai, W; Xie, H; Lee, K-H; Huang, L; Chen, C-H
Published Date
- August 14, 2014
Published In
Volume / Issue
- 5 / 8
Start / End Page
- 942 - 946
PubMed ID
- 25147619
Pubmed Central ID
- PMC4137370
International Standard Serial Number (ISSN)
- 1948-5875
Digital Object Identifier (DOI)
- 10.1021/ml500236n
Language
- eng
Conference Location
- United States