Tert promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.
Publication
, Journal Article
Yan, H; Killela, PJ; Reitman, ZJ; Jiao, Y; Bettegowda, C; Agrawal, N; Diaz, LA; Friedman, AH; Friedman, H; Gallia, GL; Giovanella, BC; He, TC ...
Published in: Neuro Oncol
July 2014
Malignant cells must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been discovered. In particular, mutations of the telomere binding proteins alpha thalassemia/mental retardation syndrome X-linked (ATRX) or death-domain associated protein (DAXX) have been shown to underlie a telomere maintenance mechanism not involving telomerase (alternative lengthening of telomeres), and point mutations in the promoter of the telomerase reverse transcriptase (TERT) gene increase telomerase expression and have been shown to occur in melanomas.
Duke Scholars
Published In
Neuro Oncol
DOI
EISSN
1523-5866
Publication Date
July 2014
Volume
16 Suppl 3
Start / End Page
iii5 / iii6
Location
England
Related Subject Headings
- Oncology & Carcinogenesis
- 3211 Oncology and carcinogenesis
- 1112 Oncology and Carcinogenesis
- 1109 Neurosciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Yan, H., Killela, P. J., Reitman, Z. J., Jiao, Y., Bettegowda, C., Agrawal, N., … Bigner, D. D. (2014). Tert promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Neuro Oncol, 16 Suppl 3, iii5–iii6. https://doi.org/10.1093/neuonc/nou206.18
Yan, H., P. J. Killela, Z. J. Reitman, Y. Jiao, C. Bettegowda, N. Agrawal, L. A. Diaz, et al. “Tert promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.” Neuro Oncol 16 Suppl 3 (July 2014): iii5–6. https://doi.org/10.1093/neuonc/nou206.18.
Yan H, Killela PJ, Reitman ZJ, Jiao Y, Bettegowda C, Agrawal N, et al. Tert promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Neuro Oncol. 2014 Jul;16 Suppl 3:iii5–6.
Yan, H., et al. “Tert promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.” Neuro Oncol, vol. 16 Suppl 3, July 2014, pp. iii5–6. Pubmed, doi:10.1093/neuonc/nou206.18.
Yan H, Killela PJ, Reitman ZJ, Jiao Y, Bettegowda C, Agrawal N, Diaz LA, Friedman AH, Friedman H, Gallia GL, Giovanella BC, Grollman AP, He TC, He Y, Hruban RH, Jallo GI, Mandahl N, Meeker AK, Mertens F, Netto GJ, Rasheed BA, Riggins GJ, Rosenquist TA, Schiffman M, Shih I, Theodorescu D, Torbenson MS, Velculescu VE, Wang TL, Wentzensen N, Wood LD, Zhang M, Healy P, Yang R, Diplas B, Wang ZH, Greer P, Zhu HS, Wang C, Carpenter A, Herndon JE, McLendon RE, Kinzler KW, Vogelstein B, Papadopoulos N, Bigner DD. Tert promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Neuro Oncol. 2014 Jul;16 Suppl 3:iii5–iii6.
Published In
Neuro Oncol
DOI
EISSN
1523-5866
Publication Date
July 2014
Volume
16 Suppl 3
Start / End Page
iii5 / iii6
Location
England
Related Subject Headings
- Oncology & Carcinogenesis
- 3211 Oncology and carcinogenesis
- 1112 Oncology and Carcinogenesis
- 1109 Neurosciences