Emerging roles for nuclear receptors in the pathogenesis of age-related macular degeneration.
Journal Article (Review)
Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly in the Western world. Over the last 30 years, our understanding of the pathogenesis of the disease has grown exponentially thanks to the results of countless epidemiology, genetic, histological, and biochemical studies. This information, in turn, has led to the identification of multiple biologic pathways potentially involved in development and progression of AMD, including but not limited to inflammation, lipid and extracellular matrix dysregulation, and angiogenesis. Nuclear receptors are a superfamily of transcription factors that have been shown to regulate many of the pathogenic pathways linked with AMD and as such they are emerging as promising targets for therapeutic intervention. In this review, we will present the fundamental phenotypic features of AMD and discuss our current understanding of the pathobiological disease mechanisms. We will introduce the nuclear receptor superfamily and discuss the current literature on their effects on AMD-related pathophysiology.
Full Text
Duke Authors
Cited Authors
- Malek, G; Lad, EM
Published Date
- December 2014
Published In
Volume / Issue
- 71 / 23
Start / End Page
- 4617 - 4636
PubMed ID
- 25156067
Pubmed Central ID
- 25156067
Electronic International Standard Serial Number (EISSN)
- 1420-9071
Digital Object Identifier (DOI)
- 10.1007/s00018-014-1709-x
Language
- eng
Conference Location
- Switzerland