Emerging roles for nuclear receptors in the pathogenesis of age-related macular degeneration.

Journal Article (Review)

Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly in the Western world. Over the last 30 years, our understanding of the pathogenesis of the disease has grown exponentially thanks to the results of countless epidemiology, genetic, histological, and biochemical studies. This information, in turn, has led to the identification of multiple biologic pathways potentially involved in development and progression of AMD, including but not limited to inflammation, lipid and extracellular matrix dysregulation, and angiogenesis. Nuclear receptors are a superfamily of transcription factors that have been shown to regulate many of the pathogenic pathways linked with AMD and as such they are emerging as promising targets for therapeutic intervention. In this review, we will present the fundamental phenotypic features of AMD and discuss our current understanding of the pathobiological disease mechanisms. We will introduce the nuclear receptor superfamily and discuss the current literature on their effects on AMD-related pathophysiology.

Full Text

Duke Authors

Cited Authors

  • Malek, G; Lad, EM

Published Date

  • December 2014

Published In

Volume / Issue

  • 71 / 23

Start / End Page

  • 4617 - 4636

PubMed ID

  • 25156067

Electronic International Standard Serial Number (EISSN)

  • 1420-9071

International Standard Serial Number (ISSN)

  • 1420-682X

Digital Object Identifier (DOI)

  • 10.1007/s00018-014-1709-x

Language

  • eng