Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults.

Journal Article (Clinical Trial;Journal Article;Multicenter Study)

Although influenza vaccination is recommended for all adults annually, the incidence of vaccine failure, defined as weak or absent increase in neutralizing Ab titers, is increased in the elderly compared with young adults. The T follicular helper cell (Tfh) subset of CD4 T cells provides B cell help in germinal centers and is necessary for class-switched Ab responses. Previous studies suggested a role for circulating Tfh cells (cTfh) following influenza vaccination in adults, but cTfh have not been studied in elderly adults in whom weak vaccine responses are often observed. In this study, we studied cTfh expressing CXCR5 and programmed death-1 (PD-1). cTfh from elderly adults were present at reduced frequency, had decreased in vitro B cell help ability, and had greater expression of ICOS compared with young adults. At 7 d after inactivated influenza vaccination, cTfh correlated with influenza vaccine-specific IgM and IgG responses in young adults but not in elderly adults. In sum, we have identified aging-related changes in cTfh that correlated with reduced influenza vaccine responses. Future rational vaccine design efforts should incorporate Tfh measurement as an immune correlate of protection, particularly in the setting of aging.

Full Text

Duke Authors

Cited Authors

  • Herati, RS; Reuter, MA; Dolfi, DV; Mansfield, KD; Aung, H; Badwan, OZ; Kurupati, RK; Kannan, S; Ertl, H; Schmader, KE; Betts, MR; Canaday, DH; Wherry, EJ

Published Date

  • October 1, 2014

Published In

Volume / Issue

  • 193 / 7

Start / End Page

  • 3528 - 3537

PubMed ID

  • 25172499

Pubmed Central ID

  • PMC4170011

Electronic International Standard Serial Number (EISSN)

  • 1550-6606

Digital Object Identifier (DOI)

  • 10.4049/jimmunol.1302503


  • eng

Conference Location

  • United States