Model-Driven Safety Analysis of Closed-Loop Medical Systems.

Journal Article (Journal Article)

In modern hospitals, patients are treated using a wide array of medical devices that are increasingly interacting with each other over the network, thus offering a perfect example of a cyber-physical system. We study the safety of a medical device system for the physiologic closed-loop control of drug infusion. The main contribution of the paper is the verification approach for the safety properties of closed-loop medical device systems. We demonstrate, using a case study, that the approach can be applied to a system of clinical importance. Our method combines simulation-based analysis of a detailed model of the system that contains continuous patient dynamics with model checking of a more abstract timed automata model. We show that the relationship between the two models preserves the crucial aspect of the timing behavior that ensures the conservativeness of the safety analysis. We also describe system design that can provide open-loop safety under network failure.

Full Text

Duke Authors

Cited Authors

  • Pajic, M; Mangharam, R; Sokolsky, O; Arney, D; Goldman, J; Lee, I

Published Date

  • October 2012

Published In

PubMed ID

  • 24177176

Pubmed Central ID

  • PMC3810414

Electronic International Standard Serial Number (EISSN)

  • 1941-0050

International Standard Serial Number (ISSN)

  • 1551-3203

Digital Object Identifier (DOI)

  • 10.1109/tii.2012.2226594


  • eng