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Pancreatic intraepithelial neoplasia and histological changes in non-neoplastic pancreas associated with neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma.

Publication ,  Journal Article
Chatterjee, D; Katz, MH; Rashid, A; Estrella, JS; Wang, H; Varadhachary, GR; Wolff, RA; Lee, JE; Pisters, PW; Abbruzzese, JL; Fleming, JB; Wang, H
Published in: Histopathology
December 2013

AIMS: To study the histological changes in non-neoplastic pancreas and the effects on pancreatic intraepithelial neoplasia (PanIN) after neoadjuvant chemoradiation therapy (NCRT) for pancreatic ductal adenocarcinoma (PDAC). METHODS AND RESULTS: We reviewed the archival H&E slides from 218 patients with PDAC who completed NCRT and pancreaticoduodenectomy. Sixty-five patients who underwent pancreaticoduodenectomy for PDAC without NCRT were used as controls. Various histological features were reviewed and correlated with NCRT and survival. The NCRT group had lower densities of PanIN2 (P = 0.004) and PanIN3 (P = 0.02) than the control group. The extent of fibrosis, the frequency of neuroma-like nerve proliferation and the frequency of islet cell aggregation were significantly higher in the NCRT group than in the control group (P < 0.05). The intensity of inflammation was less in the NCRT group than in the control group (P = 0.02). In the NCRT group, patents with moderate to severe fibrosis or grade 2 inflammation had poorer survival than those with mild fibrosis (P = 0.04) or those with grade 0 or grade 1 inflammation (P = 0.003), respectively. CONCLUSIONS: Non-neoplastic pancreatic tissue from patients who received NCRT had a reduced density of high-grade PanIN lesions, more pancreatic fibrosis, and higher frequencies of neuroma-like nerve proliferation and islet cell aggregation, but less inflammation, compared to tissue from those who did not receive NCRT.

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Published In

Histopathology

DOI

EISSN

1365-2559

Publication Date

December 2013

Volume

63

Issue

6

Start / End Page

841 / 851

Location

England

Related Subject Headings

  • Young Adult
  • Pathology
  • Pancreaticoduodenectomy
  • Pancreatic Neoplasms
  • Pancreas
  • Nervous System
  • Neoadjuvant Therapy
  • Middle Aged
  • Male
  • Islets of Langerhans
 

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Chatterjee, D., Katz, M. H., Rashid, A., Estrella, J. S., Wang, H., Varadhachary, G. R., … Fleming, J. B. (2013). Pancreatic intraepithelial neoplasia and histological changes in non-neoplastic pancreas associated with neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma. Histopathology, 63(6), 841–851. https://doi.org/10.1111/his.12234
Chatterjee, Deyali, Matthew H. Katz, Asif Rashid, Jeannelyn S. Estrella, Hua Wang, Gauri R. Varadhachary, Robert A. Wolff, et al. “Pancreatic intraepithelial neoplasia and histological changes in non-neoplastic pancreas associated with neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma.Histopathology 63, no. 6 (December 2013): 841–51. https://doi.org/10.1111/his.12234.
Chatterjee D, Katz MH, Rashid A, Estrella JS, Wang H, Varadhachary GR, et al. Pancreatic intraepithelial neoplasia and histological changes in non-neoplastic pancreas associated with neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma. Histopathology. 2013 Dec;63(6):841–51.
Chatterjee, Deyali, et al. “Pancreatic intraepithelial neoplasia and histological changes in non-neoplastic pancreas associated with neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma.Histopathology, vol. 63, no. 6, Dec. 2013, pp. 841–51. Pubmed, doi:10.1111/his.12234.
Chatterjee D, Katz MH, Rashid A, Estrella JS, Wang H, Varadhachary GR, Wolff RA, Lee JE, Pisters PW, Abbruzzese JL, Fleming JB. Pancreatic intraepithelial neoplasia and histological changes in non-neoplastic pancreas associated with neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma. Histopathology. 2013 Dec;63(6):841–851.
Journal cover image

Published In

Histopathology

DOI

EISSN

1365-2559

Publication Date

December 2013

Volume

63

Issue

6

Start / End Page

841 / 851

Location

England

Related Subject Headings

  • Young Adult
  • Pathology
  • Pancreaticoduodenectomy
  • Pancreatic Neoplasms
  • Pancreas
  • Nervous System
  • Neoadjuvant Therapy
  • Middle Aged
  • Male
  • Islets of Langerhans