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Tumor blood flow measured by perfusion computed tomography and 15O-labeled water positron emission tomography: a comparison study.

Publication ,  Journal Article
Ng, CS; Kodama, Y; Mullani, NA; Barron, BJ; Wei, W; Herbst, RS; Abbruzzese, JL; Charnsangavej, C
Published in: J Comput Assist Tomogr
2009

OBJECTIVES: To compare blood flow measurements of tumors assessed by perfusion computed tomography (pCT) and the clinical gold standard of 15O-labeled water positron emission tomography (15O-PET). METHODS: Blood flows were estimated by pCT (4-row multidetector, CT Perfusion 3.1) and 15O-PET (Posicam, first-pass model) in 14 patients with solid tumors, totaling 22 index tumors and 57 matched pairs of examinations. Blood flow estimates were compared using t test, Bland-Altman, and linear mixed regression analyses. RESULTS: There was no significant difference between the mean (SD) blood flow values measured by pCT and 15O-PET: 25.9 +/- 15.4 and 27.8 +/- 14.0 mL/min per 100 g, respectively. CONCLUSIONS: The demonstration of a good correlation between pCT and 15O-PET potentially enables the use of pCT, which is more widely available than 15O-PET, when tumor blood flow estimates are required, particularly in the context of clinical studies.

Duke Scholars

Published In

J Comput Assist Tomogr

DOI

EISSN

1532-3145

Publication Date

2009

Volume

33

Issue

3

Start / End Page

460 / 465

Location

United States

Related Subject Headings

  • Water
  • Tomography, X-Ray Computed
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiopharmaceuticals
  • Positron-Emission Tomography
  • Oxygen Radioisotopes
  • Nuclear Medicine & Medical Imaging
  • Neovascularization, Pathologic
  • Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ng, C. S., Kodama, Y., Mullani, N. A., Barron, B. J., Wei, W., Herbst, R. S., … Charnsangavej, C. (2009). Tumor blood flow measured by perfusion computed tomography and 15O-labeled water positron emission tomography: a comparison study. J Comput Assist Tomogr, 33(3), 460–465. https://doi.org/10.1097/RCT.0b013e318182d2e0
Ng, Chaan S., Yoshihisa Kodama, Nizar A. Mullani, Bruce J. Barron, Wei Wei, Roy S. Herbst, James L. Abbruzzese, and Chusilp Charnsangavej. “Tumor blood flow measured by perfusion computed tomography and 15O-labeled water positron emission tomography: a comparison study.J Comput Assist Tomogr 33, no. 3 (2009): 460–65. https://doi.org/10.1097/RCT.0b013e318182d2e0.
Ng CS, Kodama Y, Mullani NA, Barron BJ, Wei W, Herbst RS, et al. Tumor blood flow measured by perfusion computed tomography and 15O-labeled water positron emission tomography: a comparison study. J Comput Assist Tomogr. 2009;33(3):460–5.
Ng, Chaan S., et al. “Tumor blood flow measured by perfusion computed tomography and 15O-labeled water positron emission tomography: a comparison study.J Comput Assist Tomogr, vol. 33, no. 3, 2009, pp. 460–65. Pubmed, doi:10.1097/RCT.0b013e318182d2e0.
Ng CS, Kodama Y, Mullani NA, Barron BJ, Wei W, Herbst RS, Abbruzzese JL, Charnsangavej C. Tumor blood flow measured by perfusion computed tomography and 15O-labeled water positron emission tomography: a comparison study. J Comput Assist Tomogr. 2009;33(3):460–465.

Published In

J Comput Assist Tomogr

DOI

EISSN

1532-3145

Publication Date

2009

Volume

33

Issue

3

Start / End Page

460 / 465

Location

United States

Related Subject Headings

  • Water
  • Tomography, X-Ray Computed
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiopharmaceuticals
  • Positron-Emission Tomography
  • Oxygen Radioisotopes
  • Nuclear Medicine & Medical Imaging
  • Neovascularization, Pathologic
  • Neoplasms