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The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum.

Publication ,  Journal Article
Reid, DW; Chen, Q; Tay, AS-L; Shenolikar, S; Nicchitta, CV
Published in: Cell
September 11, 2014

The unfolded protein response (UPR) is a stress response program that reprograms cellular translation and gene expression in response to proteotoxic stress in the endoplasmic reticulum (ER). One of the primary means by which the UPR alleviates this stress is by reducing protein flux into the ER via a general suppression of protein synthesis and ER-specific mRNA degradation. We report here an additional UPR-induced mechanism for the reduction of protein flux into the ER, where mRNAs that encode signal sequences are released from the ER to the cytosol. By removing mRNAs from the site of translocation, this mechanism may serve as a potent means to transiently reduce ER protein folding load and restore proteostasis. These findings identify the dynamic subcellular localization of mRNAs and translation as a selective and rapid regulatory feature of the cellular response to protein folding stress.

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Published In

Cell

DOI

EISSN

1097-4172

Publication Date

September 11, 2014

Volume

158

Issue

6

Start / End Page

1362 / 1374

Location

United States

Related Subject Headings

  • Unfolded Protein Response
  • RNA, Messenger
  • Protein Biosynthesis
  • Polyribosomes
  • Open Reading Frames
  • Mice
  • Kinetics
  • Fibroblasts
  • Endoplasmic Reticulum
  • Dithiothreitol
 

Citation

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Reid, D. W., Chen, Q., Tay, A.-L., Shenolikar, S., & Nicchitta, C. V. (2014). The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum. Cell, 158(6), 1362–1374. https://doi.org/10.1016/j.cell.2014.08.012
Reid, David W., Qiang Chen, Angeline S-L Tay, Shirish Shenolikar, and Christopher V. Nicchitta. “The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum.Cell 158, no. 6 (September 11, 2014): 1362–74. https://doi.org/10.1016/j.cell.2014.08.012.
Reid DW, Chen Q, Tay AS-L, Shenolikar S, Nicchitta CV. The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum. Cell. 2014 Sep 11;158(6):1362–74.
Reid, David W., et al. “The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum.Cell, vol. 158, no. 6, Sept. 2014, pp. 1362–74. Pubmed, doi:10.1016/j.cell.2014.08.012.
Reid DW, Chen Q, Tay AS-L, Shenolikar S, Nicchitta CV. The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum. Cell. 2014 Sep 11;158(6):1362–1374.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

September 11, 2014

Volume

158

Issue

6

Start / End Page

1362 / 1374

Location

United States

Related Subject Headings

  • Unfolded Protein Response
  • RNA, Messenger
  • Protein Biosynthesis
  • Polyribosomes
  • Open Reading Frames
  • Mice
  • Kinetics
  • Fibroblasts
  • Endoplasmic Reticulum
  • Dithiothreitol