The mechanobiology of articular cartilage: bearing the burden of osteoarthritis.

Published

Journal Article (Review)

Articular cartilage injuries and degenerative joint diseases are responsible for progressive pain and disability in millions of people worldwide, yet there is currently no treatment available to restore full joint functionality. As the tissue functions under mechanical load, an understanding of the physiologic or pathologic effects of biomechanical factors on cartilage physiology is of particular interest. Here, we highlight studies that have measured cartilage deformation at scales ranging from the macroscale to the microscale, as well as the responses of the resident cartilage cells, chondrocytes, to mechanical loading using in vitro and in vivo approaches. From these studies, it is clear that there exists a complex interplay among mechanical, inflammatory, and biochemical factors that can either support or inhibit cartilage matrix homeostasis under normal or pathologic conditions. Understanding these interactions is an important step toward developing tissue engineering approaches and therapeutic interventions for cartilage pathologies, such as osteoarthritis.

Full Text

Duke Authors

Cited Authors

  • Sanchez-Adams, J; Leddy, HA; McNulty, AL; O'Conor, CJ; Guilak, F

Published Date

  • October 2014

Published In

Volume / Issue

  • 16 / 10

Start / End Page

  • 451 -

PubMed ID

  • 25182679

Pubmed Central ID

  • 25182679

Electronic International Standard Serial Number (EISSN)

  • 1534-6307

Digital Object Identifier (DOI)

  • 10.1007/s11926-014-0451-6

Language

  • eng

Conference Location

  • United States