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Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.

Publication ,  Journal Article
Mishriky, BM; Waldron, NH; Habib, AS
Published in: Br J Anaesth
January 2015

We performed this systematic review to assess the analgesic efficacy of perioperative pregabalin. Subgroup analyses and meta-regression were performed to assess the impact of individual dose and frequency of pregabalin administration on analgesic efficacy. We included 55 studies. When all doses and administration regimens were combined, pregabalin was associated with a significant reduction in pain scores at rest and during movement and opioid consumption at 24 h compared with placebo {mean difference [95% confidence interval (CI)]=-0.38 (-0.57, -0.20), -0.47 (-0.76, -0.18), and -8.27 mg morphine equivalents (-10.08, -6.47), respectively}. Patients receiving pregabalin had less postoperative nausea and vomiting and pruritus compared with placebo [relative risk (RR) (95% CI)=0.62 (0.48, 0.80) and 0.49 (0.34, 0.70), respectively]. Sedation, dizziness, and visual disturbance were more common with pregabalin compared with placebo [RR (95% CI)=1.46 (1.08, 1.98), 1.33 (1.07, 1.64), and 3.52 (2.05, 6.04), respectively]. All doses of pregabalin tested (≤75, 100-150, and 300 mg) resulted in opioid sparing at 24 h after surgery. There were no significant differences in acute pain outcomes with pregabalin 100-300 mg between single preoperative dosing regimens and those including additional doses repeated after surgery. Data were insufficient to reach conclusions regarding persistent pain, but limited data available from two studies suggested that pregabalin might be effective for the reduction of neuropathic pain. In conclusion, this review suggests that pregabalin improves postoperative analgesia compared with placebo at the expense of increased sedation and visual disturbances.

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Published In

Br J Anaesth

DOI

EISSN

1471-6771

Publication Date

January 2015

Volume

114

Issue

1

Start / End Page

10 / 31

Location

England

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Pregabalin
  • Pain, Postoperative
  • Humans
  • Chronic Pain
  • Anesthesiology
  • Analgesics
  • Acute Pain
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Mishriky, B. M., Waldron, N. H., & Habib, A. S. (2015). Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis. Br J Anaesth, 114(1), 10–31. https://doi.org/10.1093/bja/aeu293
Mishriky, B. M., N. H. Waldron, and A. S. Habib. “Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.Br J Anaesth 114, no. 1 (January 2015): 10–31. https://doi.org/10.1093/bja/aeu293.
Mishriky BM, Waldron NH, Habib AS. Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis. Br J Anaesth. 2015 Jan;114(1):10–31.
Mishriky, B. M., et al. “Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.Br J Anaesth, vol. 114, no. 1, Jan. 2015, pp. 10–31. Pubmed, doi:10.1093/bja/aeu293.
Mishriky BM, Waldron NH, Habib AS. Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis. Br J Anaesth. 2015 Jan;114(1):10–31.
Journal cover image

Published In

Br J Anaesth

DOI

EISSN

1471-6771

Publication Date

January 2015

Volume

114

Issue

1

Start / End Page

10 / 31

Location

England

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Pregabalin
  • Pain, Postoperative
  • Humans
  • Chronic Pain
  • Anesthesiology
  • Analgesics
  • Acute Pain
  • 3202 Clinical sciences
  • 1103 Clinical Sciences