Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
Journal Article (Journal Article)
Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.
Full Text
Duke Authors
Cited Authors
- Hwang, J-Y; Sim, X; Wu, Y; Liang, J; Tabara, Y; Hu, C; Hara, K; Tam, CHT; Cai, Q; Zhao, Q; Jee, S; Takeuchi, F; Go, MJ; Ong, RTH; Ohkubo, T; Kim, YJ; Zhang, R; Yamauchi, T; So, WY; Long, J; Gu, D; Lee, NR; Kim, S; Katsuya, T; Oh, JH; Liu, J; Umemura, S; Kim, Y-J; Jiang, F; Maeda, S; Chan, JCN; Lu, W; Hixson, JE; Adair, LS; Jung, KJ; Nabika, T; Bae, J-B; Lee, MH; Seielstad, M; Young, TL; Teo, YY; Kita, Y; Takashima, N; Osawa, H; Lee, S-H; Shin, M-H; Shin, DH; Choi, BY; Shi, J; Gao, Y-T; Xiang, Y-B; Zheng, W; Kato, N; Yoon, M; He, J; Shu, XO; Ma, RCW; Kadowaki, T; Jia, W; Miki, T; Qi, L; Tai, ES; Mohlke, KL; Han, B-G; Cho, YS; Kim, B-J
Published Date
- January 2015
Published In
Volume / Issue
- 64 / 1
Start / End Page
- 291 - 298
PubMed ID
- 25187374
Pubmed Central ID
- PMC4274808
Electronic International Standard Serial Number (EISSN)
- 1939-327X
Digital Object Identifier (DOI)
- 10.2337/db14-0563
Language
- eng
Conference Location
- United States