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Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.

Publication ,  Journal Article
Hwang, J-Y; Sim, X; Wu, Y; Liang, J; Tabara, Y; Hu, C; Hara, K; Tam, CHT; Cai, Q; Zhao, Q; Jee, S; Takeuchi, F; Go, MJ; Ong, RTH; Ohkubo, T ...
Published in: Diabetes
January 2015
Published version (DOI) Link to item

Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.

Duke Scholars

Terri Lois Young
Author Terri Lois Young Ophthalmology
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Published In

Diabetes

DOI

10.2337/db14-0563

EISSN

1939-327X

Publication Date

January 2015

Volume

64

Issue

1

Start / End Page

291 / 298

Location

United States

Related Subject Headings

  • Tumor Suppressor Proteins
  • Receptor, IGF Type 1
  • Pyruvate Dehydrogenase Acetyl-Transferring Kinase
  • Protein Serine-Threonine Kinases
  • Phenotype
  • Middle Aged
  • Male
  • Humans
  • Guanine Nucleotide Exchange Factors
  • Genotype
 

Citation

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Hwang, J.-Y., Sim, X., Wu, Y., Liang, J., Tabara, Y., Hu, C., … Kim, B.-J. (2015). Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. Diabetes, 64(1), 291–298. https://doi.org/10.2337/db14-0563
Hwang, Joo-Yeon, Xueling Sim, Ying Wu, Jun Liang, Yasuharu Tabara, Cheng Hu, Kazuo Hara, et al. “Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.” Diabetes 64, no. 1 (January 2015): 291–98. https://doi.org/10.2337/db14-0563.
Hwang J-Y, Sim X, Wu Y, Liang J, Tabara Y, Hu C, et al. Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. Diabetes. 2015 Jan;64(1):291–8.
Hwang, Joo-Yeon, et al. “Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.” Diabetes, vol. 64, no. 1, Jan. 2015, pp. 291–98. Pubmed, doi:10.2337/db14-0563.
Hwang J-Y, Sim X, Wu Y, Liang J, Tabara Y, Hu C, Hara K, Tam CHT, Cai Q, Zhao Q, Jee S, Takeuchi F, Go MJ, Ong RTH, Ohkubo T, Kim YJ, Zhang R, Yamauchi T, So WY, Long J, Gu D, Lee NR, Kim S, Katsuya T, Oh JH, Liu J, Umemura S, Kim Y-J, Jiang F, Maeda S, Chan JCN, Lu W, Hixson JE, Adair LS, Jung KJ, Nabika T, Bae J-B, Lee MH, Seielstad M, Young TL, Teo YY, Kita Y, Takashima N, Osawa H, Lee S-H, Shin M-H, Shin DH, Choi BY, Shi J, Gao Y-T, Xiang Y-B, Zheng W, Kato N, Yoon M, He J, Shu XO, Ma RCW, Kadowaki T, Jia W, Miki T, Qi L, Tai ES, Mohlke KL, Han B-G, Cho YS, Kim B-J. Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. Diabetes. 2015 Jan;64(1):291–298.

Published In

Diabetes

DOI

10.2337/db14-0563

EISSN

1939-327X

Publication Date

January 2015

Volume

64

Issue

1

Start / End Page

291 / 298

Location

United States

Related Subject Headings

  • Tumor Suppressor Proteins
  • Receptor, IGF Type 1
  • Pyruvate Dehydrogenase Acetyl-Transferring Kinase
  • Protein Serine-Threonine Kinases
  • Phenotype
  • Middle Aged
  • Male
  • Humans
  • Guanine Nucleotide Exchange Factors
  • Genotype