Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.

Journal Article (Journal Article)

Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.

Full Text

Duke Authors

Cited Authors

  • Hwang, J-Y; Sim, X; Wu, Y; Liang, J; Tabara, Y; Hu, C; Hara, K; Tam, CHT; Cai, Q; Zhao, Q; Jee, S; Takeuchi, F; Go, MJ; Ong, RTH; Ohkubo, T; Kim, YJ; Zhang, R; Yamauchi, T; So, WY; Long, J; Gu, D; Lee, NR; Kim, S; Katsuya, T; Oh, JH; Liu, J; Umemura, S; Kim, Y-J; Jiang, F; Maeda, S; Chan, JCN; Lu, W; Hixson, JE; Adair, LS; Jung, KJ; Nabika, T; Bae, J-B; Lee, MH; Seielstad, M; Young, TL; Teo, YY; Kita, Y; Takashima, N; Osawa, H; Lee, S-H; Shin, M-H; Shin, DH; Choi, BY; Shi, J; Gao, Y-T; Xiang, Y-B; Zheng, W; Kato, N; Yoon, M; He, J; Shu, XO; Ma, RCW; Kadowaki, T; Jia, W; Miki, T; Qi, L; Tai, ES; Mohlke, KL; Han, B-G; Cho, YS; Kim, B-J

Published Date

  • January 2015

Published In

Volume / Issue

  • 64 / 1

Start / End Page

  • 291 - 298

PubMed ID

  • 25187374

Pubmed Central ID

  • PMC4274808

Electronic International Standard Serial Number (EISSN)

  • 1939-327X

Digital Object Identifier (DOI)

  • 10.2337/db14-0563

Language

  • eng

Conference Location

  • United States