Binding forces associated with staphylococcus aureus biofilms on medical implants

Journal Article

Staphylococcus aureus is one of the most frequently isolated bacteria from infected medical implants. S. aureus has the capacity to adhere to the surface of an implant where it forms a biofilm. We used atomic force microscopy to probe binding forces between a fibronectin-coated tip and isolates of S. aureus, which were obtained from either patients with infected prostheses or healthy humans. A unique force-signature was observed for binding events between the tip and the cells. There is a statistically significant difference in the binding force-signature observed for S. aureus isolated from the infected vs. healthy populations. This observation suggests a fundamental correlation between nanometer scale binding forces and the clinical outcome of patients with implanted medical devices. © 2008 American Chemical Society.

Full Text

Duke Authors

Cited Authors

  • Yongsunthon, R; Fowler, VG; Lower, SK

Published Date

  • May 30, 2008

Published In

Volume / Issue

  • 984 /

Start / End Page

  • 189 - 197

Electronic International Standard Serial Number (EISSN)

  • 1947-5918

International Standard Serial Number (ISSN)

  • 0097-6156

Digital Object Identifier (DOI)

  • 10.1021/bk-2008-0984.ch011

Citation Source

  • Scopus