Absence of a simple code: how transcription factors read the genome.
Journal Article (Journal Article;Review)
Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a genome. TFs recognize DNA in a specific manner; the mechanisms underlying this specificity have been identified for many TFs based on 3D structures of protein-DNA complexes. More recently, structural views have been complemented with data from high-throughput in vitro and in vivo explorations of the DNA-binding preferences of many TFs. Together, these approaches have greatly expanded our understanding of TF-DNA interactions. However, the mechanisms by which TFs select in vivo binding sites and alter gene expression remain unclear. Recent work has highlighted the many variables that influence TF-DNA binding, while demonstrating that a biophysical understanding of these many factors will be central to understanding TF function.
Full Text
Duke Authors
Cited Authors
- Slattery, M; Zhou, T; Yang, L; Dantas Machado, AC; Gordân, R; Rohs, R
Published Date
- September 2014
Published In
Volume / Issue
- 39 / 9
Start / End Page
- 381 - 399
PubMed ID
- 25129887
Pubmed Central ID
- PMC4149858
International Standard Serial Number (ISSN)
- 0968-0004
Digital Object Identifier (DOI)
- 10.1016/j.tibs.2014.07.002
Language
- eng
Conference Location
- England