Absence of a simple code: how transcription factors read the genome.

Published

Journal Article (Review)

Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a genome. TFs recognize DNA in a specific manner; the mechanisms underlying this specificity have been identified for many TFs based on 3D structures of protein-DNA complexes. More recently, structural views have been complemented with data from high-throughput in vitro and in vivo explorations of the DNA-binding preferences of many TFs. Together, these approaches have greatly expanded our understanding of TF-DNA interactions. However, the mechanisms by which TFs select in vivo binding sites and alter gene expression remain unclear. Recent work has highlighted the many variables that influence TF-DNA binding, while demonstrating that a biophysical understanding of these many factors will be central to understanding TF function.

Full Text

Duke Authors

Cited Authors

  • Slattery, M; Zhou, T; Yang, L; Dantas Machado, AC; Gordân, R; Rohs, R

Published Date

  • September 2014

Published In

Volume / Issue

  • 39 / 9

Start / End Page

  • 381 - 399

PubMed ID

  • 25129887

Pubmed Central ID

  • 25129887

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/j.tibs.2014.07.002

Language

  • eng