Updating the Wnt pathways.

Published

Journal Article

In the three decades since the discovery of the Wnt1 proto-oncogene in virus-induced mouse mammary tumours, our understanding of the signalling pathways that are regulated by the Wnt proteins has progressively expanded. Wnts are involved in an complex signalling network that governs multiple biological processes and cross-talk with multiple additional signalling cascades, including the Notch, FGF (fibroblast growth factor), SHH (Sonic hedgehog), EGF (epidermal growth factor) and Hippo pathways. The Wnt signalling pathway also illustrates the link between abnormal regulation of the developmental processes and disease manifestation. Here we provide an overview of Wnt-regulated signalling cascades and highlight recent advances. We focus on new findings regarding the dedicated Wnt production and secretion pathway with potential therapeutic targets that might be beneficial for patients with Wnt-related diseases.

Full Text

Duke Authors

Cited Authors

  • Yu, J; Virshup, DM

Published Date

  • October 17, 2014

Published In

Volume / Issue

  • 34 / 5

PubMed ID

  • 25208913

Pubmed Central ID

  • 25208913

Electronic International Standard Serial Number (EISSN)

  • 1573-4935

International Standard Serial Number (ISSN)

  • 0144-8463

Digital Object Identifier (DOI)

  • 10.1042/BSR20140119

Language

  • eng