Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response.

Published online

Journal Article

Activin is an important orchestrator of wound repair, but its potential role in skin carcinogenesis has not been addressed. Here we show using different types of genetically modified mice that enhanced levels of activin in the skin promote skin tumour formation and their malignant progression through induction of a pro-tumourigenic microenvironment. This includes accumulation of tumour-promoting Langerhans cells and regulatory T cells in the epidermis. Furthermore, activin inhibits proliferation of tumour-suppressive epidermal γδ T cells, resulting in their progressive loss during tumour promotion. An increase in activin expression was also found in human cutaneous basal and squamous cell carcinomas when compared with control tissue. These findings highlight the parallels between wound healing and cancer, and suggest inhibition of activin action as a promising strategy for the treatment of cancers overexpressing this factor.

Full Text

Duke Authors

Cited Authors

  • Antsiferova, M; Huber, M; Meyer, M; Piwko-Czuchra, A; Ramadan, T; MacLeod, AS; Havran, WL; Dummer, R; Hohl, D; Werner, S

Published Date

  • December 6, 2011

Published In

Volume / Issue

  • 2 /

Start / End Page

  • 576 -

PubMed ID

  • 22146395

Pubmed Central ID

  • 22146395

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/ncomms1585

Language

  • eng

Conference Location

  • England