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Functions of skin-resident γδ T cells.

Publication ,  Journal Article
Macleod, AS; Havran, WL
Published in: Cell Mol Life Sci
July 2011

The murine epidermis contains resident T cells that express a canonical γδ TCR and arise from fetal thymic precursors. These cells are termed dendritic epidermal T cells (DETC) and use a TCR that is restricted to the skin in adult animals. DETC produce low levels of cytokines and growth factors that contribute to epidermal homeostasis. Upon activation, DETC can secrete large amounts of inflammatory molecules which participate in the communication between DETC, neighboring keratinocytes and langerhans cells. Chemokines produced by DETC may recruit inflammatory cells to the epidermis. In addition, cell-cell mediated immune responses also appear important for epidermal-T cell communication. Information is provided which supports a crucial role for DETC in inflammation, wound healing, and tumor surveillance.

Duke Scholars

Published In

Cell Mol Life Sci

DOI

EISSN

1420-9071

Publication Date

July 2011

Volume

68

Issue

14

Start / End Page

2399 / 2408

Location

Switzerland

Related Subject Headings

  • T-Lymphocytes
  • Skin
  • Receptors, Antigen, T-Cell, gamma-delta
  • Models, Immunological
  • Mice
  • Langerhans Cells
  • Keratinocytes
  • Homeostasis
  • Cell Communication
  • Biochemistry & Molecular Biology
 

Citation

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Macleod, A. S., & Havran, W. L. (2011). Functions of skin-resident γδ T cells. Cell Mol Life Sci, 68(14), 2399–2408. https://doi.org/10.1007/s00018-011-0702-x
Macleod, Amanda S., and Wendy L. Havran. “Functions of skin-resident γδ T cells.Cell Mol Life Sci 68, no. 14 (July 2011): 2399–2408. https://doi.org/10.1007/s00018-011-0702-x.
Macleod AS, Havran WL. Functions of skin-resident γδ T cells. Cell Mol Life Sci. 2011 Jul;68(14):2399–408.
Macleod, Amanda S., and Wendy L. Havran. “Functions of skin-resident γδ T cells.Cell Mol Life Sci, vol. 68, no. 14, July 2011, pp. 2399–408. Pubmed, doi:10.1007/s00018-011-0702-x.
Macleod AS, Havran WL. Functions of skin-resident γδ T cells. Cell Mol Life Sci. 2011 Jul;68(14):2399–2408.
Journal cover image

Published In

Cell Mol Life Sci

DOI

EISSN

1420-9071

Publication Date

July 2011

Volume

68

Issue

14

Start / End Page

2399 / 2408

Location

Switzerland

Related Subject Headings

  • T-Lymphocytes
  • Skin
  • Receptors, Antigen, T-Cell, gamma-delta
  • Models, Immunological
  • Mice
  • Langerhans Cells
  • Keratinocytes
  • Homeostasis
  • Cell Communication
  • Biochemistry & Molecular Biology