Functions of skin-resident γδ T cells.

Published

Journal Article (Review)

The murine epidermis contains resident T cells that express a canonical γδ TCR and arise from fetal thymic precursors. These cells are termed dendritic epidermal T cells (DETC) and use a TCR that is restricted to the skin in adult animals. DETC produce low levels of cytokines and growth factors that contribute to epidermal homeostasis. Upon activation, DETC can secrete large amounts of inflammatory molecules which participate in the communication between DETC, neighboring keratinocytes and langerhans cells. Chemokines produced by DETC may recruit inflammatory cells to the epidermis. In addition, cell-cell mediated immune responses also appear important for epidermal-T cell communication. Information is provided which supports a crucial role for DETC in inflammation, wound healing, and tumor surveillance.

Full Text

Duke Authors

Cited Authors

  • Macleod, AS; Havran, WL

Published Date

  • July 2011

Published In

Volume / Issue

  • 68 / 14

Start / End Page

  • 2399 - 2408

PubMed ID

  • 21560071

Pubmed Central ID

  • 21560071

Electronic International Standard Serial Number (EISSN)

  • 1420-9071

Digital Object Identifier (DOI)

  • 10.1007/s00018-011-0702-x

Language

  • eng

Conference Location

  • Switzerland