Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes.
Journal Article (Journal Article)
Innate immune responses involve the production of antimicrobial peptides (AMPs), chemokines, and cytokines. We report here the identification of B-cell leukemia (Bcl)-3 as a modulator of innate immune signaling in keratinocytes. In this study, it is shown that Bcl-3 is inducible by the Th2 cytokines IL-4 and IL-13 and is overexpressed in lesional skin of atopic dermatitis (AD) patients. Bcl-3 was shown to be important to cutaneous innate immune responses as silencing of Bcl-3 by small-interfering RNA (siRNA) reversed the downregulatory effect of IL-4 on the HBD3 expression. Bcl-3 silencing enhanced vitamin D3 (1,25D3)-induced gene expression of cathelicidin AMP in keratinocytes, suggesting a negative regulatory function on cathelicidin transcription. Furthermore, 1,25D3 suppressed Bcl-3 expression in vitro and in vivo. This study identified Bcl-3 as an important modulator of cutaneous innate immune responses and its possible therapeutic role in AD.
Full Text
Duke Authors
Cited Authors
- Büchau, AS; MacLeod, DT; Morizane, S; Kotol, PF; Hata, T; Gallo, RL
Published Date
- September 2009
Published In
Volume / Issue
- 129 / 9
Start / End Page
- 2148 - 2155
PubMed ID
- 19282837
Pubmed Central ID
- PMC2758924
Electronic International Standard Serial Number (EISSN)
- 1523-1747
Digital Object Identifier (DOI)
- 10.1038/jid.2009.49
Language
- eng
Conference Location
- United States