Induction of cell stress through gene transfer of an engineered heat shock transcription factor enhances tumor immunogenicity.

Journal Article

Heat shock protein expression and release is closely associated with immunogenic forms of cell death. We show that activation of the stress response within tumor cells during cell death, using an engineered form of the heat shock transcription factor, leads to an immunogenic death. Cells dying through 'stressful death' show decreased phagocytosis by macrophages in vitro. Moreover, cells expressing heat shock proteins during cell death are significantly more protective against subsequent tumor challenge. These data demonstrate the utility of activating cellular stress programs over the course of cytotoxic therapies to enhance immune responses to dying cells.

Full Text

Duke Authors

Cited Authors

  • Gough, MJ; Melcher, AA; Crittenden, MR; Sanchez-Perez, L; Voellmy, R; Vile, RG

Published Date

  • July 2004

Published In

Volume / Issue

  • 11 / 13

Start / End Page

  • 1099 - 1104

PubMed ID

  • 15103319

Electronic International Standard Serial Number (EISSN)

  • 1476-5462

International Standard Serial Number (ISSN)

  • 0969-7128

Digital Object Identifier (DOI)

  • 10.1038/sj.gt.3302274

Language

  • eng