Obesity has now emerged as 1 of the most serious public health problems facing American Indian (AI) children and adolescents. However, little is known about what factors contribute to the early development of obesity in AI children. This study explored the relationships between maternal prepregnancy BMI, feeding practices, and growth in AI infants. The findings of this study highlight the need for nurse midwives and pediatric nurse practitioners to increase AI mothers' awareness about their feeding practices, exclusive breastfeeding, and timing for solid food introduction.