Evolutionary and developmental origins of the cardiac neural crest: building a divided outflow tract.


Journal Article (Review)

The cardiac neural crest cells (CNCCs) have played an important role in the evolution and development of the vertebrate cardiovascular system: from reinforcement of the developing aortic arch arteries early in vertebrate evolution, to later orchestration of aortic arch artery remodeling into the great arteries of the heart, and finally outflow tract septation in amniotes. A critical element necessary for the evolutionary advent of outflow tract septation was the co-evolution of the cardiac neural crest cells with the second heart field. This review highlights the major transitions in vertebrate circulatory evolution, explores the evolutionary developmental origins of the CNCCs from the third stream cranial neural crest, and explores candidate signaling pathways in CNCC and outflow tract evolution drawn from our knowledge of DiGeorge Syndrome.

Full Text

Cited Authors

  • Keyte, AL; Alonzo-Johnsen, M; Hutson, MR

Published Date

  • September 16, 2014

Published In

Volume / Issue

  • 102 / 3

Start / End Page

  • 309 - 323

PubMed ID

  • 25227322

Pubmed Central ID

  • 25227322

Electronic International Standard Serial Number (EISSN)

  • 1542-9768

International Standard Serial Number (ISSN)

  • 1542-975X

Digital Object Identifier (DOI)

  • 10.1002/bdrc.21076


  • eng