Neuromodulation for mood and memory: from the engineering bench to the patient bedside.

Journal Article (Journal Article;Review)

Brain stimulation, in the form of electroconvulsive therapy (ECT), has long been a gold standard treatment for depression, but today, the field of neuromodulation is rapidly changing with the advent of newer and more precise tools to alter neuroplasticity and to treat brain-based disorders. Now there are new means to induce focal seizures, as with magnetic seizure therapy (MST), or modifications to ECT. There are also surgical approaches to target brain circuits via implanted stimulators placed in the brain or on cranial nerves. Finally, there are noninvasive subconvulsive approaches for the transcranial application of either electric or magnetic fields. Collectively, these tools have transformed the face of neurotherapeutics and informed our understanding of the brain basis of complex neurobehavioral conditions.

Full Text

Duke Authors

Cited Authors

  • Deng, Z-D; McClintock, SM; Oey, NE; Luber, B; Lisanby, SH

Published Date

  • February 2015

Published In

Volume / Issue

  • 30 /

Start / End Page

  • 38 - 43

PubMed ID

  • 25222617

Pubmed Central ID

  • PMC4342851

Electronic International Standard Serial Number (EISSN)

  • 1873-6882

Digital Object Identifier (DOI)

  • 10.1016/j.conb.2014.08.015


  • eng

Conference Location

  • England