E proteins in lymphocyte development and lymphoid diseases.

Journal Article (Journal Article;Review)

As members of the basic helix-loop-helix (bHLH) family of transcription factors, E proteins function in the immune system by directing and maintaining a vast transcriptional network that regulates cell survival, proliferation, differentiation, and function. Proper activity of this network is essential to the functionality of the immune system. Aberrations in E protein expression or function can cause numerous defects, ranging from impaired lymphocyte development and immunodeficiency to aberrant function, cancer, and autoimmunity. Additionally, disruption of inhibitor of DNA-binding (Id) proteins, natural inhibitors of E proteins, can induce additional defects in development and function. Although E proteins have been investigated for several decades, their study continues to yield novel and exciting insights into the workings of the immune system. The goal of this chapter is to discuss the various classical roles of E proteins in lymphocyte development and highlight new and ongoing research into how these roles, if compromised, can lead to disease.

Full Text

Duke Authors

Cited Authors

  • Belle, I; Zhuang, Y

Published Date

  • 2014

Published In

Volume / Issue

  • 110 /

Start / End Page

  • 153 - 187

PubMed ID

  • 25248476

Pubmed Central ID

  • PMC6504980

Electronic International Standard Serial Number (EISSN)

  • 1557-8933

Digital Object Identifier (DOI)

  • 10.1016/B978-0-12-405943-6.00004-X


  • eng

Conference Location

  • United States