The effects of intermittent pneumatic compression during cesarean delivery on fibrinolysis


Journal Article

Objectivea Pregnancy is associated with increased risk for thromboembolic events. Intermittent pneumatic compression (IPC) devices are the method of thromboprophylaxis in a nonpregnant population. The aim of this study was to examine the effects of IPC on markers of fibrinolysis during cesarean delivery. Study Designa We conducted a randomized controlled trial from April 2009 to March 2010 of women undergoing scheduled elective cesarean delivery. Forty-nine women were randomized to IPCs or usual care. All participants had three blood samples obtained: (1) baseline, (2) 1 hour after randomization, and (3) 30 minutes after cesarean delivery. Tissue-type plasminogen activator (tPA), urokinase-type plasminogen activator (uPA), thrombin-antithrombin complex (TAT), plasminogen activator inhibitor-1 (PAI-1), and plasminogen activator inhibitor-2 (PAI-2) levels were analyzed in each sample using an enzyme-linked immunosorbent assay. Statistical analysis was performed using repeated measures two-way analysis of variance with α =  0.05. Resultsa There was a time-dependent change in tPA, uPA, and PAI-1 levels following delivery but no difference in TAT and PAI-2 levels with time. There were no differences between women randomized to IPCs or usual care. Conclusiona Markers of fibrinolysis were not significantly altered by IPCs in this study of low-risk pregnant women. Further research regarding the mechanism and efficacy of IPCs in pregnant women is warranted. © 2014 by Thieme Medical Publishers, Inc..

Full Text

Duke Authors

Cited Authors

  • Reddick, KLB; Smrtka, MP; Grotegut, CA; James, AH; Brancazio, LR; Swamy, GK

Published Date

  • January 1, 2014

Published In

Volume / Issue

  • 31 / 9

Start / End Page

  • 735 - 740

Electronic International Standard Serial Number (EISSN)

  • 1098-8785

International Standard Serial Number (ISSN)

  • 0735-1631

Digital Object Identifier (DOI)

  • 10.1055/s-0033-1359720

Citation Source

  • Scopus