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Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images.

Publication ,  Journal Article
Srinivasan, PP; Kim, LA; Mettu, PS; Cousins, SW; Comer, GM; Izatt, JA; Farsiu, S
Published in: Biomed Opt Express
October 1, 2014

We present a novel fully automated algorithm for the detection of retinal diseases via optical coherence tomography (OCT) imaging. Our algorithm utilizes multiscale histograms of oriented gradient descriptors as feature vectors of a support vector machine based classifier. The spectral domain OCT data sets used for cross-validation consisted of volumetric scans acquired from 45 subjects: 15 normal subjects, 15 patients with dry age-related macular degeneration (AMD), and 15 patients with diabetic macular edema (DME). Our classifier correctly identified 100% of cases with AMD, 100% cases with DME, and 86.67% cases of normal subjects. This algorithm is a potentially impactful tool for the remote diagnosis of ophthalmic diseases.

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Published In

Biomed Opt Express

DOI

ISSN

2156-7085

Publication Date

October 1, 2014

Volume

5

Issue

10

Start / End Page

3568 / 3577

Location

United States

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics
 

Citation

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Srinivasan, P. P., Kim, L. A., Mettu, P. S., Cousins, S. W., Comer, G. M., Izatt, J. A., & Farsiu, S. (2014). Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images. Biomed Opt Express, 5(10), 3568–3577. https://doi.org/10.1364/BOE.5.003568
Srinivasan, Pratul P., Leo A. Kim, Priyatham S. Mettu, Scott W. Cousins, Grant M. Comer, Joseph A. Izatt, and Sina Farsiu. “Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images.Biomed Opt Express 5, no. 10 (October 1, 2014): 3568–77. https://doi.org/10.1364/BOE.5.003568.
Srinivasan PP, Kim LA, Mettu PS, Cousins SW, Comer GM, Izatt JA, et al. Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images. Biomed Opt Express. 2014 Oct 1;5(10):3568–77.
Srinivasan, Pratul P., et al. “Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images.Biomed Opt Express, vol. 5, no. 10, Oct. 2014, pp. 3568–77. Pubmed, doi:10.1364/BOE.5.003568.
Srinivasan PP, Kim LA, Mettu PS, Cousins SW, Comer GM, Izatt JA, Farsiu S. Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images. Biomed Opt Express. 2014 Oct 1;5(10):3568–3577.
Journal cover image

Published In

Biomed Opt Express

DOI

ISSN

2156-7085

Publication Date

October 1, 2014

Volume

5

Issue

10

Start / End Page

3568 / 3577

Location

United States

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics