Pharmacology and safety of new oral anticoagulants: The challenge of bleeding persists


Journal Article (Review)

New oral anticoagulants (NOACs) are increasingly replacing vitamin K antagonists and older parenteral agents in clinical practice. NOACs offer several advantages compared with standard agents, including rapid onset of action, fixed dosing, and no requirement for routine coagulation monitoring. However, like all anticoagulants, NOACs carry a risk of bleeding. Here, we discuss the pharmacology and safety of NOACs, with particular emphasis on the risks of bleeding associated with NOACs versus standard anticoagulants, and we provide an overview of current bleeding management strategies. © 2014 Elsevier Inc.

Full Text

Duke Authors

Cited Authors

  • Levy, JH

Published Date

  • January 1, 2014

Published In

Volume / Issue

  • 34 / 3

Start / End Page

  • 443 - 452

Electronic International Standard Serial Number (EISSN)

  • 1557-9832

International Standard Serial Number (ISSN)

  • 0272-2712

Digital Object Identifier (DOI)

  • 10.1016/j.cll.2014.06.003

Citation Source

  • Scopus