Prognostic factors in metastatic and hormonally unresponsive carcinoma of the prostate.


Journal Article

Eighty-eight patients with hormone-resistant Stage IV prostate cancer were treated with a five-drug chemotherapy program. Patient demographic data, prior therapy, symptoms, extent of disease, and laboratory studies were analyzed statistically to evaluate the association of these parameters with survival from the onset of chemotherapy. Factors associated with short survival included age greater than 65, severe bone pain, poor performance status, presence of soft tissue metastases, anemia, elevation of serum LDH, SGOT, alkaline and acid phosphatases, and prolactin, and hypoalbuminemia. Race, stage at initial diagnosis, prior radiation therapy, prior orchiectomy, and elevation of CEA had no prognostic association. We suggest that clinical trials of new therapies of hormone-resistant prostate cancer take into account the presence of these prognostic factors in the analysis of the results of therapeutic programs.

Full Text

Duke Authors

Cited Authors

  • Berry, WR; Laszlo, J; Cox, E; Walker, A; Paulson, D

Published Date

  • August 1, 1979

Published In

Volume / Issue

  • 44 / 2

Start / End Page

  • 763 - 775

PubMed ID

  • 476583

Pubmed Central ID

  • 476583

International Standard Serial Number (ISSN)

  • 0008-543X

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(197908)44:2<763::aid-cncr2820440251>;2-5


  • eng

Conference Location

  • United States