Detection of antibodies against Turkey astrovirus in humans.

Published online

Journal Article

Astroviruses are a leading cause of gastroenteritis in mammals and birds worldwide. Although historically thought to be species-specific, increasing evidence suggests that astroviruses may cross species barriers. In this report, we used enzyme-linked immunosorbent assays to screen sera from three distinct human cohorts involved in influenza studies in Memphis, TN or Chapel Hill, NC, and Midwestern poultry abattoir workers for antibodies to turkey astrovirus type 2 (TAstV-2). Surprisingly, 26% of one cohort's population was TAstV-2 positive as compared to 0 and 8.9% in the other cohorts. This cohort was composed of people with exposure to turkeys in the Midwestern United States including abattoir workers, turkey growers, and non-occupationally exposed participants. The odds of testing positive for antibodies against turkey astrovirus among abattoir workers were approximately 3 times higher than the other groups. These studies suggest that people with contact to turkeys can develop serological responses to turkey astrovirus. Further work is needed to determine if these exposures result in virus replication and/or clinical disease.

Full Text

Duke Authors

Cited Authors

  • Meliopoulos, VA; Kayali, G; Burnham, A; Oshansky, CM; Thomas, PG; Gray, GC; Beck, MA; Schultz-Cherry, S

Published Date

  • 2014

Published In

Volume / Issue

  • 9 / 5

Start / End Page

  • e96934 -

PubMed ID

  • 24826893

Pubmed Central ID

  • 24826893

Electronic International Standard Serial Number (EISSN)

  • 1932-6203

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0096934

Language

  • eng

Conference Location

  • United States