Skip to main content
Journal cover image

Epidemiology of human adenovirus and molecular characterization of human adenovirus 55 in China, 2009-2012.

Publication ,  Journal Article
Lu, Q-B; Tong, Y-G; Wo, Y; Wang, H-Y; Liu, E-M; Gray, GC; Liu, W; Cao, W-C
Published in: Influenza and other respiratory viruses
May 2014

Human adenovirus 55 (HAdV-55) has caused recent outbreaks of acute respiratory disease (ARD) among adults and military trainees. The active surveillance for HAdV infections was sparse in China, and current knowledge on the HAdV-type distributions and its molecular evolution is lacking.To acquire better understanding on the prevalence and molecular evolution of HAdV-55 strains in China, for an informed strategy for disease control and prevention.Nasopharyngeal aspirates were collected from hospitalized children with ARTI in Chongqing during 2009-2012. The genotype of HAdV isolates were determined by sequencing the partial hexon and fiber genes. Whole genome sequences of HAdV-55 were obtained for molecular evolution analysis.About 191 (8·55%) HAdV were detected in 2234 children, including 92 (48·2%) with HAdV-7, 72 (37·7%) with HAdV-3, 6 (3·1%) with HAdV-55, 5 (2·6%) with HAdV-5, 4 (2·1%) with HAdV-1, 1 (0·5%) with HAdV-2, and 11(5·8%) with untyped HAdV. Four of these children developed pneumonia, two of whom were diagnosed with severe pneumonia and/or encephalopathy. HAdV-55 isolates clustered with HAdV-11 sequences based on the hexon gene and clustered with HAdV-14 sequences based on the fiber gene and the whole genome. The overall evolutionary rates of hexon gene, fiber gene, and whole genome of HAdV-55 were estimated at 6·2 × 10(-5) s/s/y, 8·0 × 10(-5 ) s/s/y, and 1·7 × 10(-5) s/s/y, respectively.This study suggested HAdV-55 as an emerging infectious disease pathogen has conserved genetic structure and is closely related to each other. Further molecular investigation based on HAdV-55 of wider origin might facilitate understanding its diversity, dissemination, and transmission in China.

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Influenza and other respiratory viruses

DOI

EISSN

1750-2659

ISSN

1750-2640

Publication Date

May 2014

Volume

8

Issue

3

Start / End Page

302 / 308

Related Subject Headings

  • Virology
  • Phylogeny
  • Molecular Sequence Data
  • Male
  • Infant
  • Humans
  • Genome, Viral
  • Female
  • China
  • Child, Preschool
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lu, Q.-B., Tong, Y.-G., Wo, Y., Wang, H.-Y., Liu, E.-M., Gray, G. C., … Cao, W.-C. (2014). Epidemiology of human adenovirus and molecular characterization of human adenovirus 55 in China, 2009-2012. Influenza and Other Respiratory Viruses, 8(3), 302–308. https://doi.org/10.1111/irv.12232
Lu, Qing-Bin, Yi-Gang Tong, Ying Wo, Hong-Yu Wang, En-Mei Liu, Gregory C. Gray, Wei Liu, and Wu-Chun Cao. “Epidemiology of human adenovirus and molecular characterization of human adenovirus 55 in China, 2009-2012.Influenza and Other Respiratory Viruses 8, no. 3 (May 2014): 302–8. https://doi.org/10.1111/irv.12232.
Lu Q-B, Tong Y-G, Wo Y, Wang H-Y, Liu E-M, Gray GC, et al. Epidemiology of human adenovirus and molecular characterization of human adenovirus 55 in China, 2009-2012. Influenza and other respiratory viruses. 2014 May;8(3):302–8.
Lu, Qing-Bin, et al. “Epidemiology of human adenovirus and molecular characterization of human adenovirus 55 in China, 2009-2012.Influenza and Other Respiratory Viruses, vol. 8, no. 3, May 2014, pp. 302–08. Epmc, doi:10.1111/irv.12232.
Lu Q-B, Tong Y-G, Wo Y, Wang H-Y, Liu E-M, Gray GC, Liu W, Cao W-C. Epidemiology of human adenovirus and molecular characterization of human adenovirus 55 in China, 2009-2012. Influenza and other respiratory viruses. 2014 May;8(3):302–308.
Journal cover image

Published In

Influenza and other respiratory viruses

DOI

EISSN

1750-2659

ISSN

1750-2640

Publication Date

May 2014

Volume

8

Issue

3

Start / End Page

302 / 308

Related Subject Headings

  • Virology
  • Phylogeny
  • Molecular Sequence Data
  • Male
  • Infant
  • Humans
  • Genome, Viral
  • Female
  • China
  • Child, Preschool