Human metapneumovirus in turkey poults.


Journal Article

This study was conducted to reexamine the hypothesis that human metapneumovirus (hMPV) will not infect turkeys. Six groups of 2-week-old turkeys (20 per group) were inoculated oculonasally with 1 of the following: noninfected cell suspension; hMPV genotype A1, A2, B1, or B2; or avian metapneumovirus (aMPV) subtype C. Poults inoculated with hMPV showed nasal discharge days 4-9 postexposure. Specific viral RNA and antigen were detected by reverse-transcription PCR and immunohistochemical evaluation, respectively, in nasal turbinates of birds exposed to hMPV. Nasal turbinates of hMPV-infected turkeys showed inflammatory changes and mucus accumulation. Each of the 4 hMPV genotypes caused a transient infection in turkeys as evidenced by clinical signs, detection of hMPV in turbinates, and histopathologic examination. Detailed investigation of cross-species pathogenicity of hMPV and aMPV and its importance for human and animal health is needed.

Full Text

Duke Authors

Cited Authors

  • Velayudhan, BT; Nagaraja, KV; Thachil, AJ; Shaw, DP; Gray, GC; Halvorson, DA

Published Date

  • December 2006

Published In

Volume / Issue

  • 12 / 12

Start / End Page

  • 1853 - 1859

PubMed ID

  • 17235379

Pubmed Central ID

  • 17235379

International Standard Serial Number (ISSN)

  • 1080-6040

Digital Object Identifier (DOI)

  • 10.3201/eid1212.060450


  • eng

Conference Location

  • United States