Basal ganglia function, stuttering, sequencing, and repair in adult songbirds.

Journal Article

A pallial-basal-ganglia-thalamic-pallial loop in songbirds is involved in vocal motor learning. Damage to its basal ganglia part, Area X, in adult zebra finches has been noted to have no strong effects on song and its function is unclear. Here we report that neurotoxic damage to adult Area X induced changes in singing tempo and global syllable sequencing in all animals, and considerably increased syllable repetition in birds whose song motifs ended with minor repetitions before lesioning. This stuttering-like behavior started at one month, and improved over six months. Unexpectedly, the lesioned region showed considerable recovery, including immigration of newly generated or repaired neurons that became active during singing. The timing of the recovery and stuttering suggest that immature recovering activity of the circuit might be associated with stuttering. These findings indicate that even after juvenile learning is complete, the adult striatum plays a role in higher level organization of learned vocalizations.

Full Text

Duke Authors

Cited Authors

  • Kubikova, L; Bosikova, E; Cvikova, M; Lukacova, K; Scharff, C; Jarvis, ED

Published Date

  • October 13, 2014

Published In

Volume / Issue

  • 4 /

Start / End Page

  • 6590 -

PubMed ID

  • 25307086

Electronic International Standard Serial Number (EISSN)

  • 2045-2322

Digital Object Identifier (DOI)

  • 10.1038/srep06590

Language

  • eng