Virulence mechanisms and Cryptococcus neoformans pathogenesis.

Journal Article (Journal Article;Review)

The human fungal pathogen Cryptococcus neoformans is able to rapidly and effectively adapt to varying conditions, favoring its survival in the environment and in the infected host. Many microbial phenotypes have been specifically correlated with virulence in this opportunistic pathogen, such as capsule production, melanin formation, and the secretion of various proteins. Additionally, cellular features such as the cell wall and morphogenesis play important roles in the interaction of this fungus with host immune recognition and response pathways. Survival in the face of host stress also requires maintaining RNA/DNA integrity. Additionally, aging and senescence of the fungal cells determines resistance to host-derived stresses. New mechanisms regulating the expression of these virulence-associated phenotypes have been recently explored. Importantly, human clinical studies are now confirming the roles of specific microbial factors in human infections.

Full Text

Duke Authors

Cited Authors

  • Alspaugh, JA

Published Date

  • May 2015

Published In

Volume / Issue

  • 78 /

Start / End Page

  • 55 - 58

PubMed ID

  • 25256589

Pubmed Central ID

  • 25256589

Electronic International Standard Serial Number (EISSN)

  • 1096-0937

Digital Object Identifier (DOI)

  • 10.1016/j.fgb.2014.09.004


  • eng

Conference Location

  • United States