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Prediction of acute respiratory disease in current and former smokers with and without COPD.

Publication ,  Journal Article
Bowler, RP; Kim, V; Regan, E; Williams, AAA; Santorico, SA; Make, BJ; Lynch, DA; Hokanson, JE; Washko, GR; Bercz, P; Soler, X; Marchetti, N ...
Published in: Chest
October 2014

BACKGROUND: The risk factors for acute episodes of respiratory disease in current and former smokers who do not have COPD are unknown. METHODS: Eight thousand two hundred forty-six non-Hispanic white and black current and former smokers in the Genetic Epidemiology of COPD (COPDGene) cohort had longitudinal follow-up (LFU) every 6 months to determine acute respiratory episodes requiring antibiotics or systemic corticosteroids, an ED visit, or hospitalization. Negative binomial regression was used to determine the factors associated with acute respiratory episodes. A Cox proportional hazards model was used to determine adjusted hazard ratios (HRs) for time to first episode and an acute episode of respiratory disease risk score. RESULTS: At enrollment, 4,442 subjects did not have COPD, 658 had mild COPD, and 3,146 had moderate or worse COPD. Nine thousand three hundred three acute episodes of respiratory disease and 2,707 hospitalizations were reported in LFU (3,044 acute episodes of respiratory disease and 827 hospitalizations in those without COPD). Major predictors included acute episodes of respiratory disease in year prior to enrollment (HR, 1.20; 95% CI, 1.15-1.24 per exacerbation), airflow obstruction (HR, 0.94; 95% CI, 0.91-0.96 per 10% change in % predicted FEV1), and poor health-related quality of life (HR, 1.07; 95% CI, 1.06-1.08 for each 4-unit increase in St. George's Respiratory Questionnaire score). Risks were similar for those with and without COPD. CONCLUSIONS: Although acute episode of respiratory disease rates are higher in subjects with COPD, risk factors are similar, and at a population level, there are more episodes in smokers without COPD.

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Published In

Chest

DOI

EISSN

1931-3543

Publication Date

October 2014

Volume

146

Issue

4

Start / End Page

941 / 950

Location

United States

Related Subject Headings

  • United States
  • Smoking
  • Risk Factors
  • Respiratory Tract Diseases
  • Respiratory System
  • Quality of Life
  • Pulmonary Disease, Chronic Obstructive
  • Proportional Hazards Models
  • Middle Aged
  • Male
 

Citation

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Bowler, R. P., Kim, V., Regan, E., Williams, A. A. A., Santorico, S. A., Make, B. J., … Wise, R. A. (2014). Prediction of acute respiratory disease in current and former smokers with and without COPD. Chest, 146(4), 941–950. https://doi.org/10.1378/chest.13-2946
Bowler, Russell P., Victor Kim, Elizabeth Regan, André A. A. Williams, Stephanie A. Santorico, Barry J. Make, David A. Lynch, et al. “Prediction of acute respiratory disease in current and former smokers with and without COPD.Chest 146, no. 4 (October 2014): 941–50. https://doi.org/10.1378/chest.13-2946.
Bowler RP, Kim V, Regan E, Williams AAA, Santorico SA, Make BJ, et al. Prediction of acute respiratory disease in current and former smokers with and without COPD. Chest. 2014 Oct;146(4):941–50.
Bowler, Russell P., et al. “Prediction of acute respiratory disease in current and former smokers with and without COPD.Chest, vol. 146, no. 4, Oct. 2014, pp. 941–50. Pubmed, doi:10.1378/chest.13-2946.
Bowler RP, Kim V, Regan E, Williams AAA, Santorico SA, Make BJ, Lynch DA, Hokanson JE, Washko GR, Bercz P, Soler X, Marchetti N, Criner GJ, Ramsdell J, Han MK, Demeo D, Anzueto A, Comellas A, Crapo JD, Dransfield M, Wells JM, Hersh CP, MacIntyre N, Martinez F, Nath HP, Niewoehner D, Sciurba F, Sharafkhaneh A, Silverman EK, van Beek EJR, Wilson C, Wendt C, Wise RA. Prediction of acute respiratory disease in current and former smokers with and without COPD. Chest. 2014 Oct;146(4):941–950.

Published In

Chest

DOI

EISSN

1931-3543

Publication Date

October 2014

Volume

146

Issue

4

Start / End Page

941 / 950

Location

United States

Related Subject Headings

  • United States
  • Smoking
  • Risk Factors
  • Respiratory Tract Diseases
  • Respiratory System
  • Quality of Life
  • Pulmonary Disease, Chronic Obstructive
  • Proportional Hazards Models
  • Middle Aged
  • Male