Modular nanotransporters for targeted intracellular delivery of drugs: folate receptors as potential targets.

Published

Journal Article (Review)

The review is devoted to a subcellular drug delivery system, modular nanotransporters (MNT) that can penetrate into target cells and deliver a therapeutic into their subcellular compartments, particularly into the nucleus. The therapeutics which need such type of delivery belong to two groups: (i) those that exert their effect only when delivered into a certain cell compartment (like DNA delivered into the nucleus); and (ii) those drugs that are capable of exerting their effect in different parts of the cells, however there can be found a cell compartment that is the most sensitive to their effect. A particular interest attract such cytotoxic agents as Auger electron emitters which are known to be ineffective outside the cell nucleus, whereas they possess high cytotoxicity in the vicinity of nuclear DNA through the induction of non-reparable double-strand DNA breaks. The review discusses main approaches permitting to choose internalizable receptors permitting both recognition of target cells and penetration into them. Special interest attract folate receptors which become accessible to blood circulating therapeutics after malignant transformation or on activated macrophages which makes them an attractive target for both several oncological and inflammatory diseases, like atherosclerosis. In vitro and in vivo experiments demonstrated that MNT is a promising platform for targeted delivery of different therapeutics into the nuclei of target cells.

Full Text

Duke Authors

Cited Authors

  • Slastnikova, TA; Rosenkranz, AA; Zalutsky, MR; Sobolev, AS

Published Date

  • 2015

Published In

Volume / Issue

  • 21 / 9

Start / End Page

  • 1227 - 1238

PubMed ID

  • 25312738

Pubmed Central ID

  • 25312738

Electronic International Standard Serial Number (EISSN)

  • 1873-4286

Digital Object Identifier (DOI)

  • 10.2174/1381612820666141013121032

Language

  • eng

Conference Location

  • United Arab Emirates