Effect of the 5-HTTLPR polymorphism on posttraumatic stress disorder, depression, anxiety, and quality of life among Iraq and Afghanistan veterans.

Journal Article (Journal Article)

BACKGROUND AND OBJECTIVES: Posttraumatic stress disorder (PTSD), depression, anxiety, and stress are significant problems among returning veterans and are associated with reduced quality of life. DESIGN: A correlational design was used to examine the impact of a polymorphism (5-HTTLPR) in the serotonin transporter promoter gene on post-deployment adjustment among returning veterans. METHODS: A total of 186 returning Iraq and Afghanistan veterans were genotyped for the 5-HTTLPR polymorphism. Symptoms of PTSD, depression, general stress, and anxiety were assessed along with quality of life. RESULTS: After controlling for combat exposure, age, sex of the participant, and race, 5-HTTLPR had a significant multivariate effect on post-deployment adjustment, such that S' carriers reported more post-deployment adjustment problems and worse quality of life than veterans homozygous for the L' allele. This effect was larger when the analyses were restricted to veterans of European ancestry. CONCLUSIONS: Our findings suggest that veterans who carry the S' allele of the 5-HTTLPR polymorphism may be at increased risk for adjustment problems and reduced quality of life following deployments to war zones.

Full Text

Duke Authors

Cited Authors

  • Kimbrel, NA; Morissette, SB; Meyer, EC; Chrestman, R; Jamroz, R; Silvia, PJ; Beckham, JC; Young, KA

Published Date

  • 2015

Published In

Volume / Issue

  • 28 / 4

Start / End Page

  • 456 - 466

PubMed ID

  • 25314020

Pubmed Central ID

  • PMC4697759

Electronic International Standard Serial Number (EISSN)

  • 1477-2205

Digital Object Identifier (DOI)

  • 10.1080/10615806.2014.973862


  • eng

Conference Location

  • England