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Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population.

Publication ,  Journal Article
Wei, Q; Yu, D; Liu, M; Wang, M; Zhao, M; Liu, M; Jia, W; Ma, H; Fang, J; Xu, W; Chen, K; Xu, Z; Wang, J; Tian, L; Yuan, H; Chang, J ...
Published in: Nat Genet
October 2014

To identify genetic markers for laryngeal squamous cell carcinoma (LSCC), we conducted a genome-wide association study (GWAS) on 993 individuals with LSCC (cases) and 1,995 cancer-free controls from Chinese populations. The most promising variants (association P < 1 × 10(-5)) were then replicated in 3 independent sets including 2,398 cases and 2,804 controls, among which we identified 3 new susceptibility loci at 11q12 (rs174549), 6p21 (rs2857595) and 12q24 (rs10492336). The minor alleles of each of these loci showed protective effects, with odds ratios (95% confidence intervals) of 0.73 (0.68-0.78; P = 1.00 × 10(-20)), 0.78 (0.72-0.84; P = 2.43 × 10(-15)) and 0.71 (0.65-0.77; P = 4.48 × 10(-14)), respectively. None of these variants showed an interaction with smoking or drinking. This is the first GWAS to our knowledge solely on LSCC, and the findings might advance understanding of the etiology of LSCC.

Duke Scholars

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Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

October 2014

Volume

46

Issue

10

Start / End Page

1110 / 1114

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Linkage Disequilibrium
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Genetic Loci
  • Gene Frequency
 

Citation

APA
Chicago
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Wei, Q., Yu, D., Liu, M., Wang, M., Zhao, M., Jia, W., … Lin, D. (2014). Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population. Nat Genet, 46(10), 1110–1114. https://doi.org/10.1038/ng.3090
Wei, Qingyi, Dianke Yu, Mingbo Liu, Mengyun Wang, Miaoqing Zhao, Ming Liu, Weihua Jia, et al. “Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population.Nat Genet 46, no. 10 (October 2014): 1110–14. https://doi.org/10.1038/ng.3090.
Wei, Qingyi, et al. “Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population.Nat Genet, vol. 46, no. 10, Oct. 2014, pp. 1110–14. Pubmed, doi:10.1038/ng.3090.
Wei Q, Yu D, Liu M, Wang M, Zhao M, Jia W, Ma H, Fang J, Xu W, Chen K, Xu Z, Wang J, Tian L, Yuan H, Chang J, Hu Z, Wei L, Huang Y, Han Y, Liu J, Han D, Shen H, Yang S, Zheng H, Ji Q, Li D, Tan W, Wu C, Lin D. Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population. Nat Genet. 2014 Oct;46(10):1110–1114.

Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

October 2014

Volume

46

Issue

10

Start / End Page

1110 / 1114

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Linkage Disequilibrium
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Genetic Loci
  • Gene Frequency