Skip to main content
Journal cover image

SERS nanosensors and nanoreporters: golden opportunities in biomedical applications.

Publication ,  Journal Article
Vo-Dinh, T; Liu, Y; Fales, AM; Ngo, H; Wang, H-N; Register, JK; Yuan, H; Norton, SJ; Griffin, GD
Published in: Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
January 2015

This article provides an overview of recent developments and applications of surface-enhanced Raman scattering (SERS) nanosensors and nanoreporters in our laboratory for use in biochemical monitoring, medical diagnostics, and therapy. The design and fabrication of different types of plasmonics-active nanostructures are discussed. The SERS nanosensors can be used in various applications including pH sensing, protein detection, and gene diagnostics. For DNA detection the 'Molecular Sentinel' nanoprobe can be used as a homogenous bioassay in solution or on a chip platform. Gold nanostars provide an excellent multi-modality theranostic platform, combining Raman and SERS with two-photon luminescence (TPL) imaging as well as photodynamic therapy (PDT), and photothermal therapy (PTT). Plasmonics-enhanced and optically modulated delivery of nanostars into brain tumor in live animals was demonstrated; photothermal treatment of tumor vasculature may induce inflammasome activation, thus increasing the permeability of the blood brain-tumor barrier. The imaging method using TPL of gold nanostars provides an unprecedented spatial selectivity for enhanced targeted nanostar delivery to cortical tumor tissue. A quintuple-modality nanoreporter based on gold nanostars for SERS, TPL, magnetic resonance imaging (MRI), computed tomography (CT), and PTT has recently been developed. The possibility of combining spectral selectivity and high sensitivity of the SERS process with the inherent molecular specificity of bioreceptor-based nanoprobes provides a unique multiplex and selective diagnostic modality. Several examples of optical detection using SERS in combination with other detection and treatment modalities are discussed to illustrate the usefulness and potential of SERS nanosensors and nanoreporters for medical applications.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

DOI

EISSN

1939-0041

ISSN

1939-5116

Publication Date

January 2015

Volume

7

Issue

1

Start / End Page

17 / 33

Related Subject Headings

  • Spectrum Analysis, Raman
  • Reproducibility of Results
  • Photochemotherapy
  • Nanotechnology
  • Nanostructures
  • Nanoscience & Nanotechnology
  • Multimodal Imaging
  • Metal Nanoparticles
  • Hydrogen-Ion Concentration
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Vo-Dinh, T., Liu, Y., Fales, A. M., Ngo, H., Wang, H.-N., Register, J. K., … Griffin, G. D. (2015). SERS nanosensors and nanoreporters: golden opportunities in biomedical applications. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology, 7(1), 17–33. https://doi.org/10.1002/wnan.1283
Vo-Dinh, Tuan, Yang Liu, Andrew M. Fales, Hoan Ngo, Hsin-Neng Wang, Janna K. Register, Hsiangkuo Yuan, Stephen J. Norton, and Guy D. Griffin. “SERS nanosensors and nanoreporters: golden opportunities in biomedical applications.Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology 7, no. 1 (January 2015): 17–33. https://doi.org/10.1002/wnan.1283.
Vo-Dinh T, Liu Y, Fales AM, Ngo H, Wang H-N, Register JK, et al. SERS nanosensors and nanoreporters: golden opportunities in biomedical applications. Wiley interdisciplinary reviews Nanomedicine and nanobiotechnology. 2015 Jan;7(1):17–33.
Vo-Dinh, Tuan, et al. “SERS nanosensors and nanoreporters: golden opportunities in biomedical applications.Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology, vol. 7, no. 1, Jan. 2015, pp. 17–33. Epmc, doi:10.1002/wnan.1283.
Vo-Dinh T, Liu Y, Fales AM, Ngo H, Wang H-N, Register JK, Yuan H, Norton SJ, Griffin GD. SERS nanosensors and nanoreporters: golden opportunities in biomedical applications. Wiley interdisciplinary reviews Nanomedicine and nanobiotechnology. 2015 Jan;7(1):17–33.
Journal cover image

Published In

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

DOI

EISSN

1939-0041

ISSN

1939-5116

Publication Date

January 2015

Volume

7

Issue

1

Start / End Page

17 / 33

Related Subject Headings

  • Spectrum Analysis, Raman
  • Reproducibility of Results
  • Photochemotherapy
  • Nanotechnology
  • Nanostructures
  • Nanoscience & Nanotechnology
  • Multimodal Imaging
  • Metal Nanoparticles
  • Hydrogen-Ion Concentration
  • Humans