Epidermal growth factor receptor and variant III targeted immunotherapy.
Journal Article (Review)
Immunotherapeutic approaches to cancer have shown remarkable promise. A critical barrier to successfully executing such immune-mediated interventions is the selection of safe yet immunogenic targets. As patient deaths have occurred when tumor-associated antigens shared by normal tissue have been targeted by strong cellular immunotherapeutic platforms, route of delivery, target selection and the immune-mediated approach undertaken must work together to maximize efficacy with safety. Selected tumor-specific targets can spare potential toxicity to normal tissue; however, they are far less common than tumor-associated antigens and may not be present on all patients. In the context of immunotherapy for high-grade glioma, 2 of the most prominently studied antigens are the tumor-associated epidermal growth factor receptor and its tumor-specific genetic deletion variant III. In this review, we will summarize the immune-mediated strategies employed against these targets as well as the caveats particular to these approaches.
Full Text
Duke Authors
Cited Authors
- Congdon, KL; Gedeon, PC; Suryadevara, CM; Caruso, HG; Cooper, LJN; Heimberger, AB; Sampson, JH
Published Date
- October 2014
Published In
Volume / Issue
- 16 Suppl 8 /
Start / End Page
- viii20 - viii25
PubMed ID
- 25342601
Pubmed Central ID
- 25342601
Electronic International Standard Serial Number (EISSN)
- 1523-5866
Digital Object Identifier (DOI)
- 10.1093/neuonc/nou236
Language
- eng
Conference Location
- England