PDLA a potential new potent topical analgesic: a case report.

Published online

Journal Article

Polymer D-lactic acid (PDLA) is a hydrogel that has been shown to sequester L-lactate (lactate). This reaction is rapid, spontaneous, and non-enzymatic. Lactate has been shown to have many functions within the nervous system including its use as a secondary fuel to sustain neural activity and as a neuromodulator. In the central nervous system, lactate is produced in glial cells and shuttled to neurons to be used mostly as a fuel. Lactate dehydrogenase (LDH)1 is the predominant LDH isoform within neurons and unlike LDH5, it preferentially converts lactate to pyruvate which can be used to produce adenosine triphosphate (ATP). Considering that lactate is intimately involved in the sustenance of neural activity, PDLA was applied to an open wound and its effects were examined. The results showed that the application of PDLA induced topical analgesia. This may be the first report to demonstrate that sequestering lactate, a source of energy required to sustain the firing of action potentials in neurons, may produce analgesia.

Full Text

Duke Authors

Cited Authors

  • Goldberg, JS

Published Date

  • 2014

Published In

Volume / Issue

  • 7 /

Start / End Page

  • 59 - 61

PubMed ID

  • 25368530

Pubmed Central ID

  • 25368530

International Standard Serial Number (ISSN)

  • 1178-7112

Digital Object Identifier (DOI)

  • 10.2147/LRA.S72481

Language

  • eng

Conference Location

  • New Zealand