Magnetographic array for the capture and enumeration of single cells and cell pairs.

Published online

Journal Article

We present a simple microchip device consisting of an overlaid pattern of micromagnets and microwells capable of capturing magnetically labeled cells into well-defined compartments (with accuracies >95%). Its flexible design permits the programmable deposition of single cells for their direct enumeration and pairs of cells for the detailed analysis of cell-cell interactions. This cell arraying device requires no external power and can be operated solely with permanent magnets. Large scale image analysis of cells captured in this array can yield valuable information (e.g., regarding various immune parameters such as the CD4:CD8 ratio) in a miniaturized and portable platform.

Full Text

Duke Authors

Cited Authors

  • Shields, CW; Livingston, CE; Yellen, BB; López, GP; Murdoch, DM

Published Date

  • July 2014

Published In

Volume / Issue

  • 8 / 4

Start / End Page

  • 041101 -

PubMed ID

  • 25379081

Pubmed Central ID

  • 25379081

International Standard Serial Number (ISSN)

  • 1932-1058

Digital Object Identifier (DOI)

  • 10.1063/1.4885840

Language

  • eng

Conference Location

  • United States