Formal total syntheses of classic natural product target molecules via palladium-catalyzed enantioselective alkylation.


Journal Article

Pd-catalyzed enantioselective alkylation in conjunction with further synthetic elaboration enables the formal total syntheses of a number of "classic" natural product target molecules. This publication highlights recent methods for setting quaternary and tetrasubstituted tertiary carbon stereocenters to address the synthetic hurdles encountered over many decades across multiple compound classes spanning carbohydrate derivatives, terpenes, and alkaloids. These enantioselective methods will impact both academic and industrial settings, where the synthesis of stereogenic quaternary carbons is a continuing challenge.

Full Text

Duke Authors

Cited Authors

  • Liu, Y; Liniger, M; McFadden, RM; Roizen, JL; Malette, J; Reeves, CM; Behenna, DC; Seto, M; Kim, J; Mohr, JT; Virgil, SC; Stoltz, BM

Published Date

  • January 2014

Published In

Volume / Issue

  • 10 /

Start / End Page

  • 2501 - 2512

PubMed ID

  • 25383121

Pubmed Central ID

  • 25383121

Electronic International Standard Serial Number (EISSN)

  • 1860-5397

International Standard Serial Number (ISSN)

  • 1860-5397

Digital Object Identifier (DOI)

  • 10.3762/bjoc.10.261


  • eng