Post-transcriptional regulation of MTA family by microRNAs in the context of cancer.

Journal Article (Journal Article;Review)

MicroRNAs (miRNAs) are a class of 20-24 nt small non-coding RNAs that regulate a wide range of biological processes through changing the stability and translation of their target messenger RNA (mRNA) genes. Shortly after their identification, many miRNA genes have been found dysregulated in a variety of human cancers, indicating a pathological function of this gene class in mediating cancer progression. Over the past decade, accumulated literature has shown that miRNAs participate in numerous cancer-relevant processes including cell proliferation, apoptosis, differentiation, metabolism, and importantly, metastasis, which accounts for the mortality of approximately 90 % of cancer patients. Several recent publications have linked miRNAs with metastasis-associated protein (MTA) family members. Given the fact that the MTA family members are widely overexpressed in human cancers and their nature of serving as both corepressor and coactivator in gene regulation, it is intriguing to study whether certain miRNAs regulate cancer progression through modulating the expression of MTA family members. In this review, we will focus on recent advances in understanding the regulatory relationship between certain miRNAs and MTA family members.

Full Text

Duke Authors

Cited Authors

  • Zhang, Y; Wang, X-F

Published Date

  • December 2014

Published In

Volume / Issue

  • 33 / 4

Start / End Page

  • 1011 - 1016

PubMed ID

  • 25332146

Pubmed Central ID

  • PMC4245459

Electronic International Standard Serial Number (EISSN)

  • 1573-7233

Digital Object Identifier (DOI)

  • 10.1007/s10555-014-9526-0


  • eng

Conference Location

  • Netherlands